Daily Papers

With applications ranging from metabolomics to histopathology, quantitative phase microscopy (QPM) is a powerful label-free imaging modality. Despite significant advances in fast multiplexed imaging sensors and deep-learning-based inverse solvers, the throughput of QPM is currently limited by the speed of electronic hardware. Complementarily, to improve throughput further, here we propose to acquire images in a compressed form such that more information can be transferred beyond the existing electronic hardware bottleneck. To this end, we present a learnable optical compression-decompression framework that learns content-specific features. The proposed differentiable quantitative phase microscopy (partial mu) first uses learnable optical feature extractors as image compressors. The intensity representation produced by these networks is then captured by the imaging sensor. Finally, a reconstruction network running on electronic hardware decompresses the QPM images. In numerical experiments, the proposed system achieves compression of times 64 while maintaining the SSIM of sim 0.90 and PSNR of sim 30 dB on cells. The results demonstrated by our experiments open up a new pathway for achieving end-to-end optimized (i.e., optics and electronic) compact QPM systems that may provide unprecedented throughput improvements.

Inverse problems aim to determine parameters from observations, a crucial task in engineering and science. Lately, generative models, especially diffusion models, have gained popularity in this area for their ability to produce realistic solutions and their good mathematical properties. Despite their success, an important drawback of diffusion models is their sensitivity to the choice of variance schedule, which controls the dynamics of the diffusion process. Fine-tuning this schedule for specific applications is crucial but time-costly and does not guarantee an optimal result. We propose a novel approach for learning the schedule as part of the training process. Our method supports probabilistic conditioning on data, provides high-quality solutions, and is flexible, proving able to adapt to different applications with minimum overhead. This approach is tested in two unrelated inverse problems: super-resolution microscopy and quantitative phase imaging, yielding comparable or superior results to previous methods and fine-tuned diffusion models. We conclude that fine-tuning the schedule by experimentation should be avoided because it can be learned during training in a stable way that yields better results.

Correlative computational microscopy is accelerating the mapping of dynamic biological systems by integrating morphological and molecular measurements across spatial scales, from organelles to entire organisms. Visualization, measurement, and prediction of interactions among the components of biological systems can be accelerated by generalist computational imaging frameworks that relax the trade-offs imposed by multiplex dynamic imaging. This work reports a generalist framework for wave optical imaging of the architectural order (waveOrder) among biomolecules for encoding and decoding multiple specimen properties from a minimal set of acquired channels, with or without fluorescent labels. waveOrder expresses material properties in terms of elegant physically motivated basis vectors directly interpretable as phase, absorption, birefringence, diattenuation, and fluorophore density; and it expresses image data in terms of directly measurable Stokes parameters. We report a corresponding multi-channel reconstruction algorithm to recover specimen properties in multiple contrast modes. With this framework, we implement multiple 3D computational microscopy methods, including quantitative phase imaging, quantitative label-free imaging with phase and polarization, and fluorescence deconvolution imaging, across scales ranging from organelles to whole zebrafish. These advances are available via an extensible open-source computational imaging library, waveOrder, and a napari plugin, recOrder.

Cardiac magnetic resonance (CMR) is a cornerstone for diagnosing cardiovascular disease. However, it remains underutilized due to complex, time-consuming interpretation across multi-sequences, phases, quantitative measures that heavily reliant on specialized expertise. Here, we present BAAI Cardiac Agent, a multimodal intelligent system designed for end-to-end CMR interpretation. The agent integrates specialized cardiac expert models to perform automated segmentation of cardiac structures, functional quantification, tissue characterization and disease diagnosis, and generates structured clinical reports within a unified workflow. Evaluated on CMR datasets from two hospitals (2413 patients) spanning 7-types of major cardiovascular diseases, the agent achieved an area under the receiver-operating-characteristic curve exceeding 0.93 internally and 0.81 externally. In the task of estimating left ventricular function indices, the results generated by this system for core parameters such as ejection fraction, stroke volume, and left ventricular mass are highly consistent with clinical reports, with Pearson correlation coefficients all exceeding 0.90. The agent outperformed state-of-the-art models in segmentation and diagnostic tasks, and generated clinical reports showing high concordance with expert radiologists (six readers across three experience levels). By dynamically orchestrating expert models for coordinated multimodal analysis, this agent framework enables accurate, efficient CMR interpretation and highlights its potentials for complex clinical imaging workflows. Code is available at https://github.com/plantain-herb/Cardiac-Agent.

We extend our previously proposed image reconstruction method, which allows confocal microscopes to capture periodically moving objects at frequencies beyond their frame rates, to three-dimensional and two-dimensional wide-field imaging. This extension is achieved by implementing a synchronization scheme between a confocal laser scanning microscope and a function generator to ensure consistent initial phase alignment across image sequences acquired at different focal depths or fields of view. The method was demonstrated by visualizing the three-dimensional motion of silica particles attached to an aluminum bar oscillating at 100 Hz and the two-dimensional wide-field response of colloidal particles subjected to periodic pulsed excitation. Quantitative single-particle analysis confirmed that the reconstructed images accurately captured the underlying particle dynamics. The extended approach requires no additional specialized hardware and can be readily integrated with conventional confocal microscopes. Thus, it extends the applicability of confocal imaging to the fast dynamics of periodic processes in biological and soft-matter systems.

Magnetic resonance imaging (MRI) is a cornerstone of modern medical imaging. However, long image acquisition times, the need for qualitative expert analysis, and the lack of (and difficulty extracting) quantitative indicators that are sensitive to tissue health have curtailed widespread clinical and research studies. While recent machine learning methods for MRI reconstruction and analysis have shown promise for reducing this burden, these techniques are primarily validated with imperfect image quality metrics, which are discordant with clinically-relevant measures that ultimately hamper clinical deployment and clinician trust. To mitigate this challenge, we present the Stanford Knee MRI with Multi-Task Evaluation (SKM-TEA) dataset, a collection of quantitative knee MRI (qMRI) scans that enables end-to-end, clinically-relevant evaluation of MRI reconstruction and analysis tools. This 1.6TB dataset consists of raw-data measurements of ~25,000 slices (155 patients) of anonymized patient MRI scans, the corresponding scanner-generated DICOM images, manual segmentations of four tissues, and bounding box annotations for sixteen clinically relevant pathologies. We provide a framework for using qMRI parameter maps, along with image reconstructions and dense image labels, for measuring the quality of qMRI biomarker estimates extracted from MRI reconstruction, segmentation, and detection techniques. Finally, we use this framework to benchmark state-of-the-art baselines on this dataset. We hope our SKM-TEA dataset and code can enable a broad spectrum of research for modular image reconstruction and image analysis in a clinically informed manner. Dataset access, code, and benchmarks are available at https://github.com/StanfordMIMI/skm-tea.

Capturing high-quality images from only a few detected photons is a fundamental challenge in computational imaging. Single-photon avalanche diode (SPAD) sensors promise high-quality imaging in regimes where conventional cameras fail, but raw quanta frames contain only sparse, noisy, binary photon detections. Recovering a coherent image from a burst of such frames requires handling alignment, denoising, and demosaicing (for color) under noise statistics far outside those assumed by standard restoration pipelines or modern generative models. We present an approach that adapts large text-to-image latent diffusion models to the photon-limited domain of quanta burst imaging. Our method leverages the structural and semantic priors of internet-scale diffusion models while introducing mechanisms to handle Bernoulli photon statistics. By integrating latent-space restoration with burst-level spatio-temporal reasoning, our approach produces reconstructions that are both photometrically faithful and perceptually pleasing, even under high-speed motion. We evaluate the method on synthetic benchmarks and new real-world datasets, including the first color SPAD burst dataset and a challenging Deforming (XD) video benchmark. Across all settings, the approach substantially improves perceptual quality over classical and modern learning-based baselines, demonstrating the promise of adapting large generative priors to extreme photon-limited sensing. Code at https://github.com/Aryan-Garg/gQIR{https://github.com/Aryan-Garg/gQIR}.

We study the sparse phase retrieval problem, which seeks to recover a sparse signal from a limited set of magnitude-only measurements. In contrast to prevalent sparse phase retrieval algorithms that primarily use first-order methods, we propose an innovative second-order algorithm that employs a Newton-type method with hard thresholding. This algorithm overcomes the linear convergence limitations of first-order methods while preserving their hallmark per-iteration computational efficiency. We provide theoretical guarantees that our algorithm converges to the s-sparse ground truth signal x^{natural} in R^n (up to a global sign) at a quadratic convergence rate after at most O(log (Vertx^{natural} Vert /x_{min}^{natural})) iterations, using Omega(s^2log n) Gaussian random samples. Numerical experiments show that our algorithm achieves a significantly faster convergence rate than state-of-the-art methods.

We propose a novel framework for phase retrieval that leverages Langevin dynamics to enable efficient posterior sampling, yielding reconstructions that explicitly balance distortion and perceptual quality. Unlike conventional approaches that prioritize pixel-wise accuracy, our method navigates the perception-distortion tradeoff through a principled combination of stochastic sampling, learned denoising, and model-based updates. The framework comprises three variants of increasing complexity, integrating theoretically grounded Langevin inference, adaptive noise schedule learning, parallel reconstruction sampling, and warm-start initialization from classical solvers. Extensive experiments demonstrate that our method achieves state-of-the-art performance across multiple benchmarks, both in terms of fidelity and perceptual quality.

Typical quantitative MRI (qMRI) methods estimate parameter maps after image reconstructing, which is prone to biases and error propagation. We propose a Nonlinear Conjugate Gradient (NLCG) optimizer for model-based T2/T1 estimation, which incorporates U-Net regularization trained in a scan-specific manner. This end-to-end method directly estimates qMRI maps from undersampled k-space data using mono-exponential signal modeling with zero-shot scan-specific neural network regularization to enable high fidelity T1 and T2 mapping. T2 and T1 mapping results demonstrate the ability of the proposed NLCG-Net to improve estimation quality compared to subspace reconstruction at high accelerations.

Segmenting stroke lesions in Magnetic Resonance Imaging (MRI) is challenging due to diverse clinical imaging domains, with existing models struggling to generalise across different MRI acquisition parameters and sequences. In this work, we propose two novel physics-constrained approaches using synthetic quantitative MRI (qMRI) images to enhance the robustness and generalisability of segmentation models. We trained a qMRI estimation model to predict qMRI maps from MPRAGE images, which were used to simulate diverse MRI sequences for segmentation training. A second approach built upon prior work in synthetic data for stroke lesion segmentation, generating qMRI maps from a dataset of tissue labels. The proposed approaches improved over the baseline nnUNet on a variety of out-of-distribution datasets, with the second approach outperforming the prior synthetic data method.

Point-spread-function (PSF) engineering is a powerful computational imaging techniques wherein a custom phase mask is integrated into an optical system to encode additional information into captured images. Used in combination with deep learning, such systems now offer state-of-the-art performance at monocular depth estimation, extended depth-of-field imaging, lensless imaging, and other tasks. Inspired by recent advances in spatial light modulator (SLM) technology, this paper answers a natural question: Can one encode additional information and achieve superior performance by changing a phase mask dynamically over time? We first prove that the set of PSFs described by static phase masks is non-convex and that, as a result, time-averaged PSFs generated by dynamic phase masks are fundamentally more expressive. We then demonstrate, in simulation, that time-averaged dynamic (TiDy) phase masks can offer substantially improved monocular depth estimation and extended depth-of-field imaging performance.

Brain MRI scans are often found in four modalities, consisting of T1-weighted with and without contrast enhancement (T1ce and T1w), T2-weighted imaging (T2w), and Flair. Leveraging complementary information from these different modalities enables models to learn richer, more discriminative features for understanding brain anatomy, which could be used in downstream tasks such as anomaly detection. However, in clinical practice, not all MRI modalities are always available due to various reasons. This makes missing modality generation a critical challenge in medical image analysis. In this paper, we propose SLaM-DiMM, a novel missing modality generation framework that harnesses the power of diffusion models to synthesize any of the four target MRI modalities from other available modalities. Our approach not only generates high-fidelity images but also ensures structural coherence across the depth of the volume through a dedicated coherence enhancement mechanism. Qualitative and quantitative evaluations on the BraTS-Lighthouse-2025 Challenge dataset demonstrate the effectiveness of the proposed approach in synthesizing anatomically plausible and structurally consistent results. Code is available at https://github.com/BheeshmSharma/SLaM-DiMM-MICCAI-BraTS-Challenge-2025.

Polarization imaging captures the polarization state of light, revealing information invisible to the human eye yet valuable in domains such as biomedical diagnostics, autonomous driving, and remote sensing. However, conventional polarization cameras are often expensive, bulky, or both, limiting their practical use. Lensless imaging offers a compact, low-cost alternative by replacing the lens with a simple optical element like a diffuser and performing computational reconstruction, but existing lensless polarization systems suffer from limited reconstruction quality. To overcome these limitations, we introduce a RGB-guided lensless polarization imaging system that combines a compact polarization-RGB sensor with an auxiliary, widely available conventional RGB camera providing structural guidance. We reconstruct multi-angle polarization images for each RGB color channel through a two-stage pipeline: a physics-based inversion recovers an initial polarization image, followed by a Transformer-based fusion network that refines this reconstruction using the RGB guidance image from the conventional RGB camera. Our two-stage method significantly improves reconstruction quality and fidelity over lensless-only baselines, generalizes across datasets and imaging conditions, and achieves high-quality real-world results on our physical prototype lensless camera without any fine-tuning.

Quantitative susceptibility maps from magnetic resonance images can provide both prognostic and diagnostic information in multiple sclerosis, a neurodegenerative disease characterized by the formation of lesions in white matter brain tissue. In particular, susceptibility maps provide adequate contrast to distinguish between "rim" lesions, surrounded by deposited paramagnetic iron, and "non-rim" lesion types. These paramagnetic rim lesions (PRLs) are an emerging biomarker in multiple sclerosis. Much effort has been devoted to both detection and segmentation of such lesions to monitor longitudinal change. As paramagnetic rim lesions are rare, addressing this problem requires confronting the class imbalance between rim and non-rim lesions. We produce synthetic quantitative susceptibility maps of paramagnetic rim lesions and show that inclusion of such synthetic data improves classifier performance and provide a multi-channel extension to generate accompanying contrasts and probabilistic segmentation maps. We exploit the projection capability of our trained generative network to demonstrate a novel denoising approach that allows us to train on ambiguous rim cases and substantially increase the minority class. We show that both synthetic lesion synthesis and our proposed rim lesion label denoising method best approximate the unseen rim lesion distribution and improve detection in a clinically interpretable manner. We release our code and generated data at https://github.com/agr78/PRLx-GAN upon publication.

Radio interferometric imaging aims to estimate an unknown sky intensity image from degraded observations, acquired through an antenna array. In the theoretical case of a perfectly calibrated array, it has been shown that solving the corresponding imaging problem by iterative algorithms based on convex optimization and compressive sensing theory can be competitive with classical algorithms such as CLEAN. However, in practice, antenna-based gains are unknown and have to be calibrated. Future radio telescopes, such as the SKA, aim at improving imaging resolution and sensitivity by orders of magnitude. At this precision level, the direction-dependency of the gains must be accounted for, and radio interferometric imaging can be understood as a blind deconvolution problem. In this context, the underlying minimization problem is non-convex, and adapted techniques have to be designed. In this work, leveraging recent developments in non-convex optimization, we propose the first joint calibration and imaging method in radio interferometry, with proven convergence guarantees. Our approach, based on a block-coordinate forward-backward algorithm, jointly accounts for visibilities and suitable priors on both the image and the direction-dependent effects (DDEs). As demonstrated in recent works, sparsity remains the prior of choice for the image, while DDEs are modelled as smooth functions of the sky, i.e. spatially band-limited. Finally, we show through simulations the efficiency of our method, for the reconstruction of both images of point sources and complex extended sources. MATLAB code is available on GitHub.

Gastrointestinal malignancies constitute a leading cause of cancer-related mortality worldwide, with advanced-stage prognosis remaining particularly dismal. Originating as a groundbreaking technique for early gastric cancer treatment, Endoscopic Submucosal Dissection has evolved into a versatile intervention for diverse gastrointestinal lesions. While computer-assisted systems significantly enhance procedural precision and safety in ESD, their clinical adoption faces a critical bottleneck: reliable surgical phase recognition within complex endoscopic workflows. Current state-of-the-art approaches predominantly rely on multi-stage refinement architectures that iteratively optimize temporal predictions. In this paper, we present Clinical Prior Knowledge-Constrained Diffusion (CPKD), a novel generative framework that reimagines phase recognition through denoising diffusion principles while preserving the core iterative refinement philosophy. This architecture progressively reconstructs phase sequences starting from random noise and conditioned on visual-temporal features. To better capture three domain-specific characteristics, including positional priors, boundary ambiguity, and relation dependency, we design a conditional masking strategy. Furthermore, we incorporate clinical prior knowledge into the model training to improve its ability to correct phase logical errors. Comprehensive evaluations on ESD820, Cholec80, and external multi-center demonstrate that our proposed CPKD achieves superior or comparable performance to state-of-the-art approaches, validating the effectiveness of diffusion-based generative paradigms for surgical phase recognition.

Near-field multiple-input multiple-output (MIMO) radar imaging systems have recently gained significant attention. In this paper, we develop novel non-iterative deep learning-based reconstruction methods for real-time near-field MIMO imaging. The goal is to achieve high image quality with low computational cost at compressive settings. The developed approaches have two stages. In the first approach, physics-based initial stage performs adjoint operation to back-project the measurements to the image-space, and deep neural network (DNN)-based second stage converts the 3D backprojected measurements to a magnitude-only reflectivity image. Since scene reflectivities often have random phase, DNN processes directly the magnitude of the adjoint result. As DNN, 3D U-Net is used to jointly exploit range and cross-range correlations. To comparatively evaluate the significance of exploiting physics in a learning-based approach, two additional approaches that replace the physics-based first stage with fully connected layers are also developed as purely learning-based methods. The performance is also analyzed by changing the DNN architecture for the second stage to include complex-valued processing (instead of magnitude-only processing), 2D convolution kernels (instead of 3D), and ResNet architecture (instead of U-Net). Moreover, we develop a synthesizer to generate large-scale dataset for training with 3D extended targets. We illustrate the performance through experimental data and extensive simulations. The results show the effectiveness of the developed physics-based learned reconstruction approach in terms of both run-time and image quality at highly compressive settings. Our source codes and dataset are made available at GitHub.

Self-supervised deep learning has accelerated 2D natural image analysis but remains difficult to translate into 3D MRI, where data are scarce and pre-trained 2D backbones cannot capture volumetric context. We present a sequence-invariant self-supervised framework leveraging quantitative MRI (qMRI). By simulating multiple MRI contrasts from a single 3D qMRI scan and enforcing consistent representations across these contrasts, we learn anatomy-centric rather than sequence-specific features. The result is a single 3D encoder that excels across tasks and protocols. Experiments on healthy brain segmentation (IXI), stroke lesion segmentation (ARC), and MRI denoising show significant gains over baseline SSL approaches, especially in low-data settings (up to +8.3\% Dice, +4.2 dB PSNR). It also generalises to unseen sites, supporting scalable clinical use. Code and trained models are publicly available at https://github.com/liamchalcroft/contrast-squared

Deep learning has become an area of interest in most scientific areas, including physical sciences. Modern networks apply real-valued transformations on the data. Particularly, convolutions in convolutional neural networks discard phase information entirely. Many deterministic signals, such as seismic data or electrical signals, contain significant information in the phase of the signal. We explore complex-valued deep convolutional networks to leverage non-linear feature maps. Seismic data commonly has a lowcut filter applied, to attenuate noise from ocean waves and similar long wavelength contributions. Discarding the phase information leads to low-frequency aliasing analogous to the Nyquist-Shannon theorem for high frequencies. In non-stationary data, the phase content can stabilize training and improve the generalizability of neural networks. While it has been shown that phase content can be restored in deep neural networks, we show how including phase information in feature maps improves both training and inference from deterministic physical data. Furthermore, we show that the reduction of parameters in a complex network outperforms larger real-valued networks.

Solving the inverse problem is the key step in evaluating the capacity of a physical model to describe real phenomena. In medical image computing, it aligns with the classical theme of image-based model personalization. Traditionally, a solution to the problem is obtained by performing either sampling or variational inference based methods. Both approaches aim to identify a set of free physical model parameters that results in a simulation best matching an empirical observation. When applied to brain tumor modeling, one of the instances of image-based model personalization in medical image computing, the overarching drawback of the methods is the time complexity for finding such a set. In a clinical setting with limited time between imaging and diagnosis or even intervention, this time complexity may prove critical. As the history of quantitative science is the history of compression, we align in this paper with the historical tendency and propose a method compressing complex traditional strategies for solving an inverse problem into a simple database query task. We evaluated different ways of performing the database query task assessing the trade-off between accuracy and execution time. On the exemplary task of brain tumor growth modeling, we prove that the proposed method achieves one order speed-up compared to existing approaches for solving the inverse problem. The resulting compute time offers critical means for relying on more complex and, hence, realistic models, for integrating image preprocessing and inverse modeling even deeper, or for implementing the current model into a clinical workflow.

Most existing learning-based methods for solving imaging inverse problems can be roughly divided into two classes: iterative algorithms, such as plug-and-play and diffusion methods, that leverage pretrained denoisers, and unrolled architectures that are trained end-to-end for specific imaging problems. Iterative methods in the first class are computationally costly and often provide suboptimal reconstruction performance, whereas unrolled architectures are generally specific to a single inverse problem and require expensive training. In this work, we propose a novel non-iterative, lightweight architecture that incorporates knowledge about the forward operator (acquisition physics and noise parameters) without relying on unrolling. Our model is trained to solve a wide range of inverse problems beyond denoising, including deblurring, magnetic resonance imaging, computed tomography, inpainting, and super-resolution. The proposed model can be easily adapted to unseen inverse problems or datasets with a few fine-tuning steps (up to a few images) in a self-supervised way, without ground-truth references. Throughout a series of experiments, we demonstrate state-of-the-art performance from medical imaging to low-photon imaging and microscopy.

Strategies for the generation of periodic discrete structures with identical two-point correlation are developed. Starting from a pair of root structures, which are not related by translation, phase inversion or axis reflections, child structures of arbitrary resolution (i.e., pixel or voxel numbers) and number of phases (i.e., material phases/species) can be generated by means of trivial embedding based phase extension, application of kernels and/or phase coalescence, such that the generated structures inherit the two-point-correlation equivalence. Proofs of the inheritance property are provided by means of the Discrete Fourier Transform theory. A Python 3 implementation of the results is offered by the authors through the Github repository https://github.com/DataAnalyticsEngineering/EQ2PC in order to make the provided results reproducible and useful for all interested readers. Examples for the generation of structures are demonstrated, together with applications in the homogenization theory of periodic media.

Dynamic imaging addresses the recovery of a time-varying 2D or 3D object at each time instant using its undersampled measurements. In particular, in the case of dynamic tomography, only a single projection at a single view angle may be available at a time, making the problem severely ill-posed. In this work, we propose an approach, RED-PSM, which combines for the first time two powerful techniques to address this challenging imaging problem. The first, are partially separable models, which have been used to efficiently introduce a low-rank prior for the spatio-temporal object. The second is the recent Regularization by Denoising (RED), which provides a flexible framework to exploit the impressive performance of state-of-the-art image denoising algorithms, for various inverse problems. We propose a partially separable objective with RED and a computationally efficient and scalable optimization scheme with variable splitting and ADMM. Theoretical analysis proves the convergence of our objective to a value corresponding to a stationary point satisfying the first-order optimality conditions. Convergence is accelerated by a particular projection-domain-based initialization. We demonstrate the performance and computational improvements of our proposed RED-PSM with a learned image denoiser by comparing it to a recent deep-prior-based method known as TD-DIP. Although the main focus is on dynamic tomography, we also show the performance advantages of RED-PSM in a cardiac dynamic MRI setting.

Optical aberrations significantly degrade image quality in microscopy, particularly when imaging deeper into samples. These aberrations arise from distortions in the optical wavefront and can be mathematically represented using Zernike polynomials. Existing methods often address only mild aberrations on limited sample types and modalities, typically treating the problem as a black-box mapping without leveraging the underlying optical physics of wavefront distortions. We propose ZRNet, a physics-informed framework that jointly performs Zernike coefficient prediction and optical image Restoration. We contribute a Zernike Graph module that explicitly models physical relationships between Zernike polynomials based on their azimuthal degrees-ensuring that learned corrections align with fundamental optical principles. To further enforce physical consistency between image restoration and Zernike prediction, we introduce a Frequency-Aware Alignment (FAA) loss, which better aligns Zernike coefficient prediction and image features in the Fourier domain. Extensive experiments on CytoImageNet demonstrates that our approach achieves state-of-the-art performance in both image restoration and Zernike coefficient prediction across diverse microscopy modalities and biological samples with complex, large-amplitude aberrations. Code is available at https://github.com/janetkok/ZRNet.

Near-field radar imaging systems are recently used in a wide range of applications, such as medical diagnosis, through-wall imaging, concealed weapon detection, and nondestructive evaluation. In this paper, we consider the problem of reconstructing the three-dimensional (3D) complex-valued reflectivity distribution of the near-field scene from sparse multiple-input multiple-output (MIMO) array measurements. Using the alternating direction method of multipliers (ADMM) framework, we solve this inverse problem by enforcing regularization on the magnitude of the complex-valued reflectivity distribution. For this, we provide a general expression for the proximal mapping associated with such regularization functionals. This equivalently corresponds to the solution of a complex-valued denoising problem which involves regularization on the magnitude. By utilizing this expression, we develop a novel and efficient plug-and-play (PnP) reconstruction method that consists of simple update steps. Due to the success of data-adaptive deep priors in various imaging problems, we also train a 3D deep denoiser to exploit within the developed PnP framework for MIMO imaging. The effectiveness of the developed learning-based PnP approach is illustrated under various compressive and noisy observation scenarios using both simulated data and experimental measurements. The performance is also compared with sparsity priors and the commonly used analytical approaches such as back-projection and Kirchhoff migration. The results demonstrate that the developed technique not only provides state-of-the-art reconstruction performance for 3D real-world targets, but also enables fast computation. Our approach provides a unified general framework to effectively handle arbitrary regularization on the magnitude of a complex-valued unknown and is equally applicable to other radar image formation problems (including SAR).

In recent years, the demand for hyperspectral imaging devices has grown significantly, driven by their ability of capturing high-resolution spectral information. Among the several possible optical designs for acquiring hyperspectral images, there is a growing interest in interferometric spectral imaging systems based on division of aperture. These systems have the advantage of capturing snapshot acquisitions while maintaining a compact design. However, they require a careful calibration to operate properly. In this work, we present the interferometer response characterization algorithm (IRCA), a robust three-step procedure designed to characterize the transmittance response of multi-aperture imaging spectrometers based on the interferometry of Fabry-Perot. Additionally, we propose a formulation of the image formation model for such devices suitable to estimate the parameters of interest by considering the model under various regimes of finesse. The proposed algorithm processes the image output obtained from a set of monochromatic light sources and refines the results using nonlinear regression after an ad-hoc initialization. Through experimental analysis conducted on four different prototypes from the Image SPectrometer On Chip (ImSPOC) family, we validate the performance of our approach for characterization. The associated source code for this paper is available at https://github.com/danaroth83/irca.

Diffusion models have been recently studied as powerful generative inverse problem solvers, owing to their high quality reconstructions and the ease of combining existing iterative solvers. However, most works focus on solving simple linear inverse problems in noiseless settings, which significantly under-represents the complexity of real-world problems. In this work, we extend diffusion solvers to efficiently handle general noisy (non)linear inverse problems via approximation of the posterior sampling. Interestingly, the resulting posterior sampling scheme is a blended version of diffusion sampling with the manifold constrained gradient without a strict measurement consistency projection step, yielding a more desirable generative path in noisy settings compared to the previous studies. Our method demonstrates that diffusion models can incorporate various measurement noise statistics such as Gaussian and Poisson, and also efficiently handle noisy nonlinear inverse problems such as Fourier phase retrieval and non-uniform deblurring. Code available at https://github.com/DPS2022/diffusion-posterior-sampling

Reliable visual monitoring of chemical experiments remains challenging in transparent glassware, where weak phase boundaries and optical artifacts degrade conventional segmentation. We formulate laboratory phenomena as the time evolution of phase interfaces and introduce the Chemical Transparent Glasses dataset 2.0 (CTG 2.0), a vessel-aware benchmark with 3,668 images, 23 glassware categories, and five multiphase interface types for phase-interface instance segmentation. Building on YOLO11m-seg, we propose LGA-RCM-YOLO, which combines Local-Global Attention (LGA) for robust semantic representation and a Rectangular Self-Calibration Module (RCM) for boundary refinement of thin, elongated interfaces. On CTG 2.0, the proposed model achieves 84.4% AP@0.5 and 58.43% AP@0.5-0.95, improving over the YOLO11m baseline by 6.42 and 8.75 AP points, respectively, while maintaining near real-time inference (13.67 FPS, RTX 3060). An auxiliary color-attribute head further labels liquid instances as colored or colorless with 98.71% precision and 98.32% recall. Finally, we demonstrate continuous process monitoring in separatory-funnel phase separation and crystallization, showing that phase-interface instance segmentation can serve as a practical visual sensor for laboratory automation.

Diffusion models have recently achieved success in solving Bayesian inverse problems with learned data priors. Current methods build on top of the diffusion sampling process, where each denoising step makes small modifications to samples from the previous step. However, this process struggles to correct errors from earlier sampling steps, leading to worse performance in complicated nonlinear inverse problems, such as phase retrieval. To address this challenge, we propose a new method called Decoupled Annealing Posterior Sampling (DAPS) that relies on a novel noise annealing process. Specifically, we decouple consecutive steps in a diffusion sampling trajectory, allowing them to vary considerably from one another while ensuring their time-marginals anneal to the true posterior as we reduce noise levels. This approach enables the exploration of a larger solution space, improving the success rate for accurate reconstructions. We demonstrate that DAPS significantly improves sample quality and stability across multiple image restoration tasks, particularly in complicated nonlinear inverse problems. For example, we achieve a PSNR of 30.72dB on the FFHQ 256 dataset for phase retrieval, which is an improvement of 9.12dB compared to existing methods.

Lensless imaging enables compact and versatile computational cameras by replacing bulky optics with thin coded elements. However, reconstruction from the resulting measurements is challenging: large-footprint point-spread functions (PSFs) produce highly multiplexed observations, making inversion severely ill-conditioned and sensitive to calibration errors and model mismatch. While deep learning approaches, including hybrid models that incorporate physics priors, have shown promise, explicitly maintaining data fidelity throughout the network hierarchy remains difficult. Here, we propose the Integrated Forward-Inverse Network (IFIN), a physics-guided architecture that interleaves differentiable forward projections with learnable inverse updates at every scale, enabling complementary cues to be exploited jointly in the measurement and image domains. This bidirectional coupling supports progressive, physics-consistent refinement and permits system-constrained PSF kernel adaptation under model uncertainty. On challenging lensless benchmarks, including a newly introduced dataset, IFIN achieves state-of-the-art reconstruction quality. We further observe competitive performance on Gaussian deblurring and simulated inline holography reconstruction, suggesting that the same interleaving principle can extend beyond lensless cameras.

This study addresses the challenging problem of active view selection and uncertainty quantification within the domain of Radiance Fields. Neural Radiance Fields (NeRF) have greatly advanced image rendering and reconstruction, but the limited availability of 2D images poses uncertainties stemming from occlusions, depth ambiguities, and imaging errors. Efficiently selecting informative views becomes crucial, and quantifying NeRF model uncertainty presents intricate challenges. Existing approaches either depend on model architecture or are based on assumptions regarding density distributions that are not generally applicable. By leveraging Fisher Information, we efficiently quantify observed information within Radiance Fields without ground truth data. This can be used for the next best view selection and pixel-wise uncertainty quantification. Our method overcomes existing limitations on model architecture and effectiveness, achieving state-of-the-art results in both view selection and uncertainty quantification, demonstrating its potential to advance the field of Radiance Fields. Our method with the 3D Gaussian Splatting backend could perform view selections at 70 fps.

While deep learning has advanced speech enhancement (SE), effective phase modeling remains challenging, as conventional networks typically operate within a flat Euclidean feature space, which is not easy to model the underlying circular topology of the phase. To address this, we propose a manifold-aware magnitude-phase dual-stream framework that aligns the phase stream with its intrinsic circular geometry by enforcing Global Rotation Equivariance (GRE) characteristic. Specifically, we introduce a Magnitude-Phase Interactive Convolutional Module (MPICM) for modulus-based information exchange and a Hybrid-Attention Dual-FFN (HADF) bottleneck for unified feature fusion, both of which are designed to preserve GRE in the phase stream. Comprehensive evaluations are conducted across phase retrieval, denoising, dereverberation, and bandwidth extension tasks to validate the superiority of the proposed method over multiple advanced baselines. Notably, the proposed architecture reduces Phase Distance by over 20\% in the phase retrieval task and improves PESQ by more than 0.1 in zero-shot cross-corpus denoising evaluations. The overall superiority is also established in universal SE tasks involving mixed distortions. Qualitative analysis further reveals that the learned phase features exhibit distinct periodic patterns, which are consistent with the intrinsic circular nature of the phase. The source code is available at https://github.com/wangchengzhong/RENet.

Fourier PlenOctrees have shown to be an efficient representation for real-time rendering of dynamic Neural Radiance Fields (NeRF). Despite its many advantages, this method suffers from artifacts introduced by the involved compression when combining it with recent state-of-the-art techniques for training the static per-frame NeRF models. In this paper, we perform an in-depth analysis of these artifacts and leverage the resulting insights to propose an improved representation. In particular, we present a novel density encoding that adapts the Fourier-based compression to the characteristics of the transfer function used by the underlying volume rendering procedure and leads to a substantial reduction of artifacts in the dynamic model. Furthermore, we show an augmentation of the training data that relaxes the periodicity assumption of the compression. We demonstrate the effectiveness of our enhanced Fourier PlenOctrees in the scope of quantitative and qualitative evaluations on synthetic and real-world scenes.

Magnetic Resonance Imaging with tagging (tMRI) has long been utilized for quantifying tissue motion and strain during deformation. However, a phenomenon known as tag fading, a gradual decrease in tag visibility over time, often complicates post-processing. The first contribution of this study is to model tag fading by considering the interplay between T_1 relaxation and the repeated application of radio frequency (RF) pulses during serial imaging sequences. This is a factor that has been overlooked in prior research on tMRI post-processing. Further, we have observed an emerging trend of utilizing raw tagged MRI within a deep learning-based (DL) registration framework for motion estimation. In this work, we evaluate and analyze the impact of commonly used image similarity objectives in training DL registrations on raw tMRI. This is then compared with the Harmonic Phase-based approach, a traditional approach which is claimed to be robust to tag fading. Our findings, derived from both simulated images and an actual phantom scan, reveal the limitations of various similarity losses in raw tMRI and emphasize caution in registration tasks where image intensity changes over time.

Ultra-High-Definition (UHD) photo has gradually become the standard configuration in advanced imaging devices. The new standard unveils many issues in existing approaches for low-light image enhancement (LLIE), especially in dealing with the intricate issue of joint luminance enhancement and noise removal while remaining efficient. Unlike existing methods that address the problem in the spatial domain, we propose a new solution, UHDFour, that embeds Fourier transform into a cascaded network. Our approach is motivated by a few unique characteristics in the Fourier domain: 1) most luminance information concentrates on amplitudes while noise is closely related to phases, and 2) a high-resolution image and its low-resolution version share similar amplitude patterns.Through embedding Fourier into our network, the amplitude and phase of a low-light image are separately processed to avoid amplifying noise when enhancing luminance. Besides, UHDFour is scalable to UHD images by implementing amplitude and phase enhancement under the low-resolution regime and then adjusting the high-resolution scale with few computations. We also contribute the first real UHD LLIE dataset, UHD-LL, that contains 2,150 low-noise/normal-clear 4K image pairs with diverse darkness and noise levels captured in different scenarios. With this dataset, we systematically analyze the performance of existing LLIE methods for processing UHD images and demonstrate the advantage of our solution. We believe our new framework, coupled with the dataset, would push the frontier of LLIE towards UHD. The code and dataset are available at https://li-chongyi.github.io/UHDFour.

Photoacoustic computed tomography (PACT) is a non-invasive imaging modality, similar to ultrasound, with wide-ranging medical applications. Conventional PACT images are degraded by wavefront distortion caused by the heterogeneous speed of sound (SOS) in tissue. Accounting for these effects can improve image quality and provide medically useful information, but measuring the SOS directly is burdensome and the existing joint reconstruction method is computationally expensive. Traditional supervised learning techniques are currently inaccessible in this data-starved domain. In this work, we introduce an efficient, self-supervised joint reconstruction method that recovers SOS and high-quality images for ring array PACT systems. To solve this semi-blind inverse problem, we parametrize the SOS using either a pixel grid or a neural field (NF) and update it directly by backpropagating the gradients through a differentiable imaging forward model. Our method removes SOS aberrations more accurately and 35x faster than the current SOTA. We demonstrate the success of our method quantitatively in simulation and qualitatively on experimentally-collected and in vivo data. Our code and synthetic numerical phantoms are available on our project page: https://lukeli0425.github.io/Coord-SoS-PACT/.

We obtain the multiple-parameter quantum Cram\'er-Rao bound for estimating the transverse Cartesian components of the centroid and separation of two incoherent optical point sources using an imaging system with finite spatial bandwidth. Under quite general and realistic assumptions on the point-spread function of the imaging system, and for weak source strengths, we show that the Cram\'er-Rao bounds for the x and y components of the separation are independent of the values of those components, which may be well below the conventional Rayleigh resolution limit. We also propose two linear optics-based measurement methods that approach the quantum bound for the estimation of the Cartesian components of the separation once the centroid has been located. One of the methods is an interferometric scheme that approaches the quantum bound for sub-Rayleigh separations. The other method using fiber coupling can in principle attain the bound regardless of the distance between the two sources.

Metalenses offer significant potential for ultra-compact computational imaging but face challenges from complex optical degradation and computational restoration difficulties. Existing methods typically rely on precise optical calibration or massive paired datasets, which are non-trivial for real-world imaging systems. Furthermore, a lack of control over the inference process often results in undesirable hallucinated artifacts. We introduce Degradation-Modeled Multipath Diffusion for tunable metalens photography, leveraging powerful natural image priors from pretrained models instead of large datasets. Our framework uses positive, neutral, and negative-prompt paths to balance high-frequency detail generation, structural fidelity, and suppression of metalens-specific degradation, alongside pseudo data augmentation. A tunable decoder enables controlled trade-offs between fidelity and perceptual quality. Additionally, a spatially varying degradation-aware attention (SVDA) module adaptively models complex optical and sensor-induced degradation. Finally, we design and build a millimeter-scale MetaCamera for real-world validation. Extensive results show that our approach outperforms state-of-the-art methods, achieving high-fidelity and sharp image reconstruction. More materials: https://dmdiff.github.io/.

Four-dimensional computed tomography (4D CT) reconstruction is crucial for capturing dynamic anatomical changes but faces inherent limitations from conventional phase-binning workflows. Current methods discretize temporal resolution into fixed phases with respiratory gating devices, introducing motion misalignment and restricting clinical practicality. In this paper, We propose X^2-Gaussian, a novel framework that enables continuous-time 4D-CT reconstruction by integrating dynamic radiative Gaussian splatting with self-supervised respiratory motion learning. Our approach models anatomical dynamics through a spatiotemporal encoder-decoder architecture that predicts time-varying Gaussian deformations, eliminating phase discretization. To remove dependency on external gating devices, we introduce a physiology-driven periodic consistency loss that learns patient-specific breathing cycles directly from projections via differentiable optimization. Extensive experiments demonstrate state-of-the-art performance, achieving a 9.93 dB PSNR gain over traditional methods and 2.25 dB improvement against prior Gaussian splatting techniques. By unifying continuous motion modeling with hardware-free period learning, X^2-Gaussian advances high-fidelity 4D CT reconstruction for dynamic clinical imaging. Code is publicly available at: https://x2-gaussian.github.io/.

Capturing real world lighting is a long standing challenge in imaging and most practical methods acquire High Dynamic Range (HDR) images by either fusing multiple exposures, or boosting the dynamic range of Standard Dynamic Range (SDR) images. Multiple exposure capture is problematic as it requires longer capture times which can often lead to ghosting problems. The main alternative, inverse tone mapping is an ill-defined problem that is especially challenging as single captured exposures usually contain clipped and quantized values, and are therefore missing substantial amounts of content. To alleviate this, we propose a new approach, High Dynamic Range Thermal (HDRT), for HDR acquisition using a separate, commonly available, thermal infrared (IR) sensor. We propose a novel deep neural method (HDRTNet) which combines IR and SDR content to generate HDR images. HDRTNet learns to exploit IR features linked to the RGB image and the IR-specific parameters are subsequently used in a dual branch method that fuses features at shallow layers. This produces an HDR image that is significantly superior to that generated using naive fusion approaches. To validate our method, we have created the first HDR and thermal dataset, and performed extensive experiments comparing HDRTNet with the state-of-the-art. We show substantial quantitative and qualitative quality improvements on both over- and under-exposed images, showing that our approach is robust to capturing in multiple different lighting conditions.

This paper presents a smartphone-based imaging system capable of quantifying the concentration of an assortment of biological/chemical assay samples. The main objective is to construct an image database which characterizes the relationship between color information and concentrations of the biological/chemical assay sample. For this aim, a designated optical setup combined with image processing and data analyzing techniques was implemented. A series of experiments conducted on selected assays, including fluorescein, RNA Mango, homogenized milk and yeast have demonstrated that the proposed system estimates the concentration of fluorescent materials and colloidal mixtures comparable to currently used commercial and laboratory instruments. Furthermore, by utilizing the camera and computational power of smartphones, eventual development can be directed toward extremely compact, inexpensive and portable analysis and diagnostic systems which will allow experiments and tests to be conducted in remote or impoverished areas.

Polarization-based underwater 3D imaging exploits polarization cues to suppress background scattering, exhibiting distinct advantages in turbid water. Although data-driven polarization-based underwater 3D reconstruction methods show great potential, existing public datasets lack sufficient diversity in scattering and observation conditions, hindering fair comparisons among different approaches, including single-view and multi-view polarization imaging methods. To address this limitation, we construct MuS-Polar3D, a benchmark dataset comprising polarization images of 42 objects captured under seven quantitatively controlled scattering conditions and five viewpoints, together with high-precision 3D models (+/- 0.05 mm accuracy), normal maps, and foreground masks. The dataset supports multiple vision tasks, including normal estimation, object segmentation, descattering, and 3D reconstruction. Inspired by computational imaging, we further decouple underwater 3D reconstruction under scattering into a two-stage pipeline, namely descattering followed by 3D reconstruction, from an imaging-chain perspective. Extensive evaluations using multiple baseline methods under complex scattering conditions demonstrate the effectiveness of the proposed benchmark, achieving a best mean angular error of 15.49 degrees. To the best of our knowledge, MuS-Polar3D is the first publicly available benchmark dataset for quantitative turbidity underwater polarization-based 3D imaging, enabling accurate reconstruction and fair algorithm evaluation under controllable scattering conditions. The dataset and code are publicly available at https://github.com/WangPuyun/MuS-Polar3D.

Relightable object acquisition is a key challenge in simplifying digital asset creation. Complete reconstruction of an object typically requires capturing hundreds to thousands of photographs under controlled illumination, with specialized equipment. The recent progress in differentiable rendering improved the quality and accessibility of inverse rendering optimization. Nevertheless, under uncontrolled illumination and unstructured viewpoints, there is no guarantee that the observations contain enough information to reconstruct the appearance properties of the captured object. We thus propose to consider the acquisition process from a signal-processing perspective. Given an object's geometry and a lighting environment, we estimate the properties of the materials on the object's surface in seconds. We do so by leveraging frequency domain analysis, considering the recovery of material properties as a deconvolution, enabling fast error estimation. We then quantify the uncertainty of the estimation, based on the available data, highlighting the areas for which priors or additional samples would be required for improved acquisition quality. We compare our approach to previous work and quantitatively evaluate our results, showing similar quality as previous work in a fraction of the time, and providing key information about the certainty of the results.

Lensless cameras disregard the conventional design that imaging should mimic the human eye. This is done by replacing the lens with a thin mask, and moving image formation to the digital post-processing. State-of-the-art lensless imaging techniques use learned approaches that combine physical modeling and neural networks. However, these approaches make simplifying modeling assumptions for ease of calibration and computation. Moreover, the generalizability of learned approaches to lensless measurements of new masks has not been studied. To this end, we utilize a modular learned reconstruction in which a key component is a pre-processor prior to image recovery. We theoretically demonstrate the pre-processor's necessity for standard image recovery techniques (Wiener filtering and iterative algorithms), and through extensive experiments show its effectiveness for multiple lensless imaging approaches and across datasets of different mask types (amplitude and phase). We also perform the first generalization benchmark across mask types to evaluate how well reconstructions trained with one system generalize to others. Our modular reconstruction enables us to use pre-trained components and transfer learning on new systems to cut down weeks of tedious measurements and training. As part of our work, we open-source four datasets, and software for measuring datasets and for training our modular reconstruction.

We demonstrate a compact, cost-effective snapshot spectral imaging system named Aperture Diffraction Imaging Spectrometer (ADIS), which consists only of an imaging lens with an ultra-thin orthogonal aperture mask and a mosaic filter sensor, requiring no additional physical footprint compared to common RGB cameras. Then we introduce a new optical design that each point in the object space is multiplexed to discrete encoding locations on the mosaic filter sensor by diffraction-based spatial-spectral projection engineering generated from the orthogonal mask. The orthogonal projection is uniformly accepted to obtain a weakly calibration-dependent data form to enhance modulation robustness. Meanwhile, the Cascade Shift-Shuffle Spectral Transformer (CSST) with strong perception of the diffraction degeneration is designed to solve a sparsity-constrained inverse problem, realizing the volume reconstruction from 2D measurements with Large amount of aliasing. Our system is evaluated by elaborating the imaging optical theory and reconstruction algorithm with demonstrating the experimental imaging under a single exposure. Ultimately, we achieve the sub-super-pixel spatial resolution and high spectral resolution imaging. The code will be available at: https://github.com/Krito-ex/CSST.

We propose in this work a novel iterative direct sampling method for imaging moving inhomogeneities in parabolic problems using boundary measurements. It can efficiently identify the locations and shapes of moving inhomogeneities when very limited data are available, even with only one pair of lateral Cauchy data, and enjoys remarkable numerical stability for noisy data and over an extended time horizon. The method is formulated in an abstract framework, and is applicable to linear and nonlinear parabolic problems, including linear, nonlinear, and mixed-type inhomogeneities. Numerical experiments across diverse scenarios show its effectiveness and robustness against the data noise.

Magnetic resonance imaging (MRI) is highly susceptible to patient motion due to its relatively long acquisition times and the fact that data are acquired sequentially in k-space. Even small patient movements introduce phase inconsistencies across measurements, leading to severe artifacts such as blurring, ghosting, and geometric distortions that can compromise diagnostic quality. Retrospective motion compensation remains challenging, particularly in accelerated acquisitions, due to the ill-posed nature of the joint reconstruction and motion estimation problem. In this work, we propose a unified Bayesian framework for motion-compensated 3D MRI that jointly estimates the anatomical image, rigid-body motion parameters, and coil sensitivity maps directly from motion-corrupted k-space data. Our approach integrates pretrained 3D complex-valued score-based diffusion models as expressive anatomical image priors within a physics-based forward model. Inference is performed by alternating diffusion posterior image updates with efficient proximal optimization steps for motion and coil sensitivity estimation, enabling fully unsupervised reconstruction without the need for paired motion-free training data. Experiments on simulated and real-motion brain MRI datasets demonstrate that the proposed method achieves improved image quality and motion robustness compared to state-of-the-art classical and learning-based motion correction techniques, particularly in the presence of severe motion and high acceleration.

Magnetic resonance imaging (MRI) super-resolution is vital for improving diagnostic accessibility, yet most methods treat it as a deterministic mapping from a fixed low-resolution input to a high-resolution target. This overlooks a key property of MRI acquisition physics: spatial resolution and signal-to-noise ratio (SNR) are inherently coupled, making any given low-resolution scan merely one of many possible realizations under varying acquisition trade-offs. We rethink MRI super-resolution as a physics-aware reconstruction problem, in which the goal is to identify the optimal resolution-SNR configuration and then super-resolve it to obtain high-quality MRI results. A key implication of this formulation is that MRI resolution becomes dynamic rather than fixed. To handle such resolution-heterogeneous inputs, we adapt 2D Gaussian Splatting (2D GS) to MRI by formulating reconstruction as a coordinate-based, resolution-agnostic rendering problem. To further enhance fidelity, we introduce three innovations: (1) a prior-aware Gaussian representation that combines an Anatomical Structure Prior for tissue-specific kernel initialization with an Imaging System Prior that captures hardware characteristics via a covariance dictionary; (2) a physics-constrained signal modeling scheme that predicts intrinsic tissue parameters (proton density rho and effective relaxation rate R2) and synthesizes intensities through governing physical equations, ensuring biophysically plausible contrast; and (3) a meta-learning framework that alleviates paired-data scarcity by pretraining on simulated data and adapting to real-world conditions. Extensive experiments on dynamic-resolution datasets and standard benchmarks demonstrate that our method achieves state-of-the-art performance, highlighting its strong potential for clinical deployment.

Surgical phase recognition is a basic component for different context-aware applications in computer- and robot-assisted surgery. In recent years, several methods for automatic surgical phase recognition have been proposed, showing promising results. However, a meaningful comparison of these methods is difficult due to differences in the evaluation process and incomplete reporting of evaluation details. In particular, the details of metric computation can vary widely between different studies. To raise awareness of potential inconsistencies, this paper summarizes common deviations in the evaluation of phase recognition algorithms on the Cholec80 benchmark. In addition, a structured overview of previously reported evaluation results on Cholec80 is provided, taking known differences in evaluation protocols into account. Greater attention to evaluation details could help achieve more consistent and comparable results on the surgical phase recognition task, leading to more reliable conclusions about advancements in the field and, finally, translation into clinical practice.

Prostate cancer is one of the most common and lethal cancers among men, making its early detection critically important. Although ultrasound imaging offers greater accessibility and cost-effectiveness compared to MRI, traditional transrectal ultrasound methods suffer from low sensitivity, especially in detecting anteriorly located tumors. Ultrasound computed tomography provides quantitative tissue characterization, but its clinical implementation faces significant challenges, particularly under anatomically constrained limited-angle acquisition conditions specific to prostate imaging. To address these unmet needs, we introduce OpenPros, the first large-scale benchmark dataset explicitly developed for limited-view prostate USCT. Our dataset includes over 280,000 paired samples of realistic 2D speed-of-sound (SOS) phantoms and corresponding ultrasound full-waveform data, generated from anatomically accurate 3D digital prostate models derived from real clinical MRI/CT scans and ex vivo ultrasound measurements, annotated by medical experts. Simulations are conducted under clinically realistic configurations using advanced finite-difference time-domain and Runge-Kutta acoustic wave solvers, both provided as open-source components. Through comprehensive baseline experiments, we demonstrate that state-of-the-art deep learning methods surpass traditional physics-based approaches in both inference efficiency and reconstruction accuracy. Nevertheless, current deep learning models still fall short of delivering clinically acceptable high-resolution images with sufficient accuracy. By publicly releasing OpenPros, we aim to encourage the development of advanced machine learning algorithms capable of bridging this performance gap and producing clinically usable, high-resolution, and highly accurate prostate ultrasound images. The dataset is publicly accessible at https://open-pros.github.io/.

Lensless imaging stands out as a promising alternative to conventional lens-based systems, particularly in scenarios demanding ultracompact form factors and cost-effective architectures. However, such systems are fundamentally governed by the Point Spread Function (PSF), which dictates how a point source contributes to the final captured signal. Traditional lensless techniques often require explicit calibrations and extensive pre-processing, relying on static or approximate PSF models. These rigid strategies can result in limited adaptability to real-world challenges, including noise, system imperfections, and dynamic scene variations, thus impeding high-fidelity reconstruction. In this paper, we propose LensNet, an end-to-end deep learning framework that integrates spatial-domain and frequency-domain representations in a unified pipeline. Central to our approach is a learnable Coded Mask Simulator (CMS) that enables dynamic, data-driven estimation of the PSF during training, effectively mitigating the shortcomings of fixed or sparsely calibrated kernels. By embedding a Wiener filtering component, LensNet refines global structure and restores fine-scale details, thus alleviating the dependency on multiple handcrafted pre-processing steps. Extensive experiments demonstrate LensNet's robust performance and superior reconstruction quality compared to state-of-the-art methods, particularly in preserving high-frequency details and attenuating noise. The proposed framework establishes a novel convergence between physics-based modeling and data-driven learning, paving the way for more accurate, flexible, and practical lensless imaging solutions for applications ranging from miniature sensors to medical diagnostics. The link of code is https://github.com/baijiesong/Lensnet.

This paper presents a NeRF-based framework for point cloud (PCD) reconstruction, specifically designed for indoor high-throughput plant phenotyping facilities. Traditional NeRF-based reconstruction methods require cameras to move around stationary objects, but this approach is impractical for high-throughput environments where objects are rapidly imaged while moving on conveyors or rotating pedestals. To address this limitation, we develop a variant of NeRF-based PCD reconstruction that uses a single stationary camera to capture images as the object rotates on a pedestal. Our workflow comprises COLMAP-based pose estimation, a straightforward pose transformation to simulate camera movement, and subsequent standard NeRF training. A defined Region of Interest (ROI) excludes irrelevant scene data, enabling the generation of high-resolution point clouds (10M points). Experimental results demonstrate excellent reconstruction fidelity, with precision-recall analyses yielding an F-score close to 100.00 across all evaluated plant objects. Although pose estimation remains computationally intensive with a stationary camera setup, overall training and reconstruction times are competitive, validating the method's feasibility for practical high-throughput indoor phenotyping applications. Our findings indicate that high-quality NeRF-based 3D reconstructions are achievable using a stationary camera, eliminating the need for complex camera motion or costly imaging equipment. This approach is especially beneficial when employing expensive and delicate instruments, such as hyperspectral cameras, for 3D plant phenotyping. Future work will focus on optimizing pose estimation techniques and further streamlining the methodology to facilitate seamless integration into automated, high-throughput 3D phenotyping pipelines.

Multi-Resolution Hash Encoding (MHE), the foundational technique behind Instant Neural Graphics Primitives, provides a powerful parameterization for neural fields. However, its spatial behavior lacks rigorous understanding from a physical systems perspective, leading to reliance on heuristics for hyperparameter selection. This work introduces a novel analytical approach that characterizes MHE by examining its Point Spread Function (PSF), which is analogous to the Green's function of the system. This methodology enables a quantification of the encoding's spatial resolution and fidelity. We derive a closed-form approximation for the collision-free PSF, uncovering inherent grid-induced anisotropy and a logarithmic spatial profile. We establish that the idealized spatial bandwidth, specifically the Full Width at Half Maximum (FWHM), is determined by the average resolution, N_{avg}. This leads to a counterintuitive finding: the effective resolution of the model is governed by the broadened empirical FWHM (and therefore N_{avg}), rather than the finest resolution N_{max}, a broadening effect we demonstrate arises from optimization dynamics. Furthermore, we analyze the impact of finite hash capacity, demonstrating how collisions introduce speckle noise and degrade the Signal-to-Noise Ratio (SNR). Leveraging these theoretical insights, we propose Rotated MHE (R-MHE), an architecture that applies distinct rotations to the input coordinates at each resolution level. R-MHE mitigates anisotropy while maintaining the efficiency and parameter count of the original MHE. This study establishes a methodology based on physical principles that moves beyond heuristics to characterize and optimize MHE.

We revisit quantum phase estimation algorithms for the purpose of obtaining the energy levels of many-body Hamiltonians and pay particular attention to the statistical analysis of their outputs. We introduce the mean phase direction of the parent distribution associated with eigenstate inputs as a new post-processing tool. By connecting it with the unknown phase, we find that if used as its direct estimator, it exceeds the accuracy of the standard majority rule using one less bit of resolution, making evident that it can also be inverted to provide unbiased estimation. Moreover, we show how to directly use this quantity to accurately find the energy levels when the initialized state is an eigenstate of the simulated propagator during the whole time evolution, which allows for shallower algorithms. We then use IBM Q hardware to carry out the digital quantum simulation of three toy models: a two-level system, a two-spin Ising model and a two-site Hubbard model at half-filling. Methodologies are provided to implement Trotterization and reduce the variability of results in noisy intermediate scale quantum computers.

Hong-Ou-Mandel (HOM) interference is an intrinsic quantum phenomena that goes beyond the possibilities of classical physics, and enables various applications in quantum metrology. While the timing resolution of HOM-based sensor is generally investigated, the ultimate quantum sensitivity in the estimation of transverse deflection or displacement between paired photons interfering at a balanced beam splitter has been explored relatively little. Here, we present an experimental demonstration of a spatial HOM interferometry for measuring the transverse deflection of an optical beam by using transverse momentum sampling measurements. This feasible scheme suffices to achieve great precision with comparatively little technological effort, which circumvents the stringent requirement in direct imaging resolution at the diffraction limit. We can adaptively determine optimum working points using a Fisher information analysis, and demonstrate an optimized spatial HOM interferometry according to practical applications. These results may significantly facilitate the use of quantum interference for high precision spatial sensing, and pave the way to more complex quantum imaging techniques like nanoscopic microscopy.

Intelligent robots need to interact with diverse objects across various environments. The appearance and state of objects frequently undergo complex transformations depending on the object properties, e.g., phase transitions. However, in the vision community, segmenting dynamic objects with phase transitions is overlooked. In light of this, we introduce the concept of phase in segmentation, which categorizes real-world objects based on their visual characteristics and potential morphological and appearance changes. Then, we present a new benchmark, Multi-Phase, Multi-Transition, and Multi-Scenery Video Object Segmentation (M^3-VOS), to verify the ability of models to understand object phases, which consists of 479 high-resolution videos spanning over 10 distinct everyday scenarios. It provides dense instance mask annotations that capture both object phases and their transitions. We evaluate state-of-the-art methods on M^3-VOS, yielding several key insights. Notably, current appearance-based approaches show significant room for improvement when handling objects with phase transitions. The inherent changes in disorder suggest that the predictive performance of the forward entropy-increasing process can be improved through a reverse entropy-reducing process. These findings lead us to propose ReVOS, a new plug-andplay model that improves its performance by reversal refinement. Our data and code will be publicly available at https://zixuan-chen.github.io/M-cube-VOS.github.io/.

Dynamic contrast-enhanced (DCE) MRI is essential for breast cancer diagnosis and treatment. However, its reliance on contrast agents introduces safety concerns, contraindications, increased cost, and workflow complexity. To this end, we present pre-contrast conditioned denoising diffusion probabilistic models to synthesize DCE-MRI, introducing, evaluating, and comparing a total of 22 generative model variants in both single-breast and full breast settings. Towards enhancing lesion fidelity, we introduce both tumor-aware loss functions and explicit tumor segmentation mask conditioning. Using a public multicenter dataset and comparing to respective pre-contrast baselines, we observe that subtraction image-based models consistently outperform post-contrast-based models across five complementary evaluation metrics. Apart from assessing the entire image, we also separately evaluate the region of interest, where both tumor-aware losses and segmentation mask inputs improve evaluation metrics. The latter notably enhance qualitative results capturing contrast uptake, albeit assuming access to tumor localization inputs that are not guaranteed to be available in screening settings. A reader study involving 2 radiologists and 4 MRI technologists confirms the high realism of the synthetic images, indicating an emerging clinical potential of generative contrast-enhancement. We share our codebase at https://github.com/sebastibar/conditional-diffusion-breast-MRI.

Intracellular lasers are emerging as powerful biosensors for multiplexed tracking and precision sensing of cells and their microenvironment. This sensing capacity is enabled by quantifying their narrow-linewidth emission spectra, which is presently challenging to do at high speeds. In this work, we demonstrate rapid snapshot hyperspectral imaging of intracellular lasers. Using integral field mapping with a microlens array and a diffraction grating, we obtain images of the spatial and spectral intensity distribution from a single camera acquisition. We demonstrate widefield hyperspectral imaging over a 3times3 mm^2 field of view and volumetric imaging over 250times250times800 mum^3 volumes with a spatial resolution of 5 mum and a spectral resolution of less than 0.8 nm. We evaluate the performance and outline the challenges and strengths of snapshot methods in the context of characterising the emission from intracellular lasers. This method offers new opportunities for a diverse range of applications, including high-throughput and long-term biosensing with intracellular lasers.

In this article, we introduce a novel algorithm for efficient near-field synthetic aperture radar (SAR) imaging for irregular scanning geometries. With the emergence of fifth-generation (5G) millimeter-wave (mmWave) devices, near-field SAR imaging is no longer confined to laboratory environments. Recent advances in positioning technology have attracted significant interest for a diverse set of new applications in mmWave imaging. However, many use cases, such as automotive-mounted SAR imaging, unmanned aerial vehicle (UAV) imaging, and freehand imaging with smartphones, are constrained to irregular scanning geometries. Whereas traditional near-field SAR imaging systems and quick personnel security (QPS) scanners employ highly precise motion controllers to create ideal synthetic arrays, emerging applications, mentioned previously, inherently cannot achieve such ideal positioning. In addition, many Internet of Things (IoT) and 5G applications impose strict size and computational complexity limitations that must be considered for edge mmWave imaging technology. In this study, we propose a novel algorithm to leverage the advantages of non-cooperative SAR scanning patterns, small form-factor multiple-input multiple-output (MIMO) radars, and efficient monostatic planar image reconstruction algorithms. We propose a framework to mathematically decompose arbitrary and irregular sampling geometries and a joint solution to mitigate multistatic array imaging artifacts. The proposed algorithm is validated through simulations and an empirical study of arbitrary scanning scenarios. Our algorithm achieves high-resolution and high-efficiency near-field MIMO-SAR imaging, and is an elegant solution to computationally constrained irregularly sampled imaging problems.

Whenever we use devices to take measurements, calibration is indispensable. While the purpose of calibration is to reduce bias and uncertainty in the measurements, it can be quite difficult, expensive, and sometimes even impossible to implement. We study a challenging problem called self-calibration, i.e., the task of designing an algorithm for devices so that the algorithm is able to perform calibration automatically. More precisely, we consider the setup y = A(d) x + epsilon where only partial information about the sensing matrix A(d) is known and where A(d) linearly depends on d. The goal is to estimate the calibration parameter d (resolve the uncertainty in the sensing process) and the signal/object of interests x simultaneously. For three different models of practical relevance, we show how such a bilinear inverse problem, including blind deconvolution as an important example, can be solved via a simple linear least squares approach. As a consequence, the proposed algorithms are numerically extremely efficient, thus potentially allowing for real-time deployment. We also present a variation of the least squares approach, which leads to a~spectral method, where the solution to the bilinear inverse problem can be found by computing the singular vector associated with the smallest singular value of a certain matrix derived from the bilinear system. Explicit theoretical guarantees and stability theory are derived for both techniques; and the number of sampling complexity is nearly optimal (up to a poly-log factor). Applications in imaging sciences and signal processing are discussed and numerical simulations are presented to demonstrate the effectiveness and efficiency of our approach.

Post-merger gravitational wave echoes provide a unique opportunity to probe the near-horizon structure of astrophysical black holes, that may be modified due to non-perturbative quantum gravity phenomena. However, since the waveform is subject to large theoretical uncertainties, it is necessary to develop model-agnostic search methods for detecting echoes from observational data. A promising strategy is to identify the characteristic quasinormal modes (QNMs) associated with echoes, {\it in frequency space}, which complements existing searches of quasiperiodic pulses in time. In this study, we build upon our previous work targeting these modes by incorporating relative phase information to optimize the Bayesian search algorithm. Using a new phase-marginalized likelihood, the performance can be significantly improved for well-resolved QNMs. This enables an efficient model-agnostic search for QNMs of different shapes by using a simple search template. To demonstrate the robustness of the search algorithm, we construct four complementary benchmarks for the echo waveform that span a diverse range of different theoretical possibilities for the near-horizon structure. We then validate our Bayesian search algorithms by injecting the benchmark models into different realizations of Gaussian noise. Using two types of phase-marginalized likelihoods, we find that the search algorithm can efficiently detect the corresponding QNMs. Therefore, our search strategy provides a concrete Bayesian and model-agnostic approach to "quantum black hole seismology".

Ultrasonic acoustic fields have recently been used to generate haptic effects on the human skin as well as to levitate small sub-wavelength size particles. Schlieren imaging and background-oriented schlieren techniques can be used for acoustic wave pattern and beam shape visualization. These techniques exploit variations in the refractive index of a propagation medium by applying refractive optics or cross-correlation algorithms of photographs of illuminated background patterns. Here both background-oriented and traditional schlieren systems are used to visualize the regions of the acoustic power involved in creating dynamic haptic sensations and dynamic levitation traps. We demonstrate for the first time the application of back-ground-oriented schlieren for imaging ultrasonic fields in air. We detail our imaging apparatus and present improved algorithms used to visualize these phenomena that we have produced using multiple phased arrays. Moreover, to improve imaging, we leverage an electronically controlled, high-output LED which is pulsed in synchrony with the ultrasonic carrier frequency.

Music source separation in the time-frequency domain is commonly achieved by applying a soft or binary mask to the magnitude component of (complex) spectrograms. The phase component is usually not estimated, but instead copied from the mixture and applied to the magnitudes of the estimated isolated sources. While this method has several practical advantages, it imposes an upper bound on the performance of the system, where the estimated isolated sources inherently exhibit audible "phase artifacts". In this paper we address these shortcomings by directly estimating masks in the complex domain, extending recent work from the speech enhancement literature. The method is particularly well suited for multi-instrument musical source separation since residual phase artifacts are more pronounced for spectrally overlapping instrument sources, a common scenario in music. We show that complex masks result in better separation than masks that operate solely on the magnitude component.

We study the behavior of deterministic methods for solving inverse problems in imaging. These methods are commonly designed to achieve two goals: (1) attaining high perceptual quality, and (2) generating reconstructions that are consistent with the measurements. We provide a rigorous proof that the better a predictor satisfies these two requirements, the larger its Lipschitz constant must be, regardless of the nature of the degradation involved. In particular, to approach perfect perceptual quality and perfect consistency, the Lipschitz constant of the model must grow to infinity. This implies that such methods are necessarily more susceptible to adversarial attacks. We demonstrate our theory on single image super-resolution algorithms, addressing both noisy and noiseless settings. We also show how this undesired behavior can be leveraged to explore the posterior distribution, thereby allowing the deterministic model to imitate stochastic methods.

In-line digital holography (DIH) is a widely used lensless imaging technique, valued for its simplicity and capability to image samples at high throughput. However, capturing only intensity of the interference pattern during the recording process gives rise to some unwanted terms such as cross-term and twin-image. The cross-term can be suppressed by adjusting the intensity of reference wave, but the twin-image problem remains. The twin-image is a spectral artifact that superimposes a defocused conjugate wave onto the reconstructed object, severely degrading image quality. While deep learning has recently emerged as a powerful tool for phase retrieval, traditional Convolutional Neural Networks (CNNs) are limited by their local receptive fields, making them less effective at capturing the global diffraction patterns inherent in holography. In this study, we introduce HoloPASWIN, a physics-aware deep learning framework based on the Swin Transformer architecture. By leveraging hierarchical shifted-window attention, our model efficiently captures both local details and long-range dependencies essential for accurate holographic reconstruction. We propose a comprehensive loss function that integrates frequency-domain constraints with physical consistency via a differentiable angular spectrum propagator, ensuring high spectral fidelity. Validated on a large-scale synthetic dataset of 25,000 samples with diverse noise configurations (speckle, shot, read, and dark noise), HoloPASWIN demonstrates effective twin-image suppression and robust reconstruction quality.

This paper presents a data-driven, task-specific paradigm for experimental design, to shorten acquisition time, reduce costs, and accelerate the deployment of imaging devices. Current approaches in experimental design focus on model-parameter estimation and require specification of a particular model, whereas in imaging, other tasks may drive the design. Furthermore, such approaches often lead to intractable optimization problems in real-world imaging applications. Here we present a new paradigm for experimental design that simultaneously optimizes the design (set of image channels) and trains a machine-learning model to execute a user-specified image-analysis task. The approach obtains data densely-sampled over the measurement space (many image channels) for a small number of acquisitions, then identifies a subset of channels of prespecified size that best supports the task. We propose a method: TADRED for TAsk-DRiven Experimental Design in imaging, to identify the most informative channel-subset whilst simultaneously training a network to execute the task given the subset. Experiments demonstrate the potential of TADRED in diverse imaging applications: several clinically-relevant tasks in magnetic resonance imaging; and remote sensing and physiological applications of hyperspectral imaging. Results show substantial improvement over classical experimental design, two recent application-specific methods within the new paradigm, and state-of-the-art approaches in supervised feature selection. We anticipate further applications of our approach. Code is available: https://github.com/sbb-gh/experimental-design-multichannel

High dynamic range (HDR) imaging is of fundamental importance in modern digital photography pipelines and used to produce a high-quality photograph with well exposed regions despite varying illumination across the image. This is typically achieved by merging multiple low dynamic range (LDR) images taken at different exposures. However, over-exposed regions and misalignment errors due to poorly compensated motion result in artefacts such as ghosting. In this paper, we present a new HDR imaging technique that specifically models alignment and exposure uncertainties to produce high quality HDR results. We introduce a strategy that learns to jointly align and assess the alignment and exposure reliability using an HDR-aware, uncertainty-driven attention map that robustly merges the frames into a single high quality HDR image. Further, we introduce a progressive, multi-stage image fusion approach that can flexibly merge any number of LDR images in a permutation-invariant manner. Experimental results show our method can produce better quality HDR images with up to 1.1dB PSNR improvement to the state-of-the-art, and subjective improvements in terms of better detail, colours, and fewer artefacts.

Endoscopic Submucosal Dissection (ESD) is a minimally invasive procedure initially developed for early gastric cancer treatment and has expanded to address diverse gastrointestinal lesions. While computer-assisted surgery (CAS) systems enhance ESD precision and safety, their efficacy hinges on accurate real-time surgical phase recognition, a task complicated by ESD's inherent complexity, including heterogeneous lesion characteristics and dynamic tissue interactions. Existing video-based phase recognition algorithms, constrained by inefficient temporal context modeling, exhibit limited performance in capturing fine-grained phase transitions and long-range dependencies. To overcome these limitations, we propose SPRMamba, a novel framework integrating a Mamba-based architecture with a Scaled Residual TranMamba (SRTM) block to synergize long-term temporal modeling and localized detail extraction. SPRMamba further introduces the Hierarchical Sampling Strategy to optimize computational efficiency, enabling real-time processing critical for clinical deployment. Evaluated on the ESD385 dataset and the cholecystectomy benchmark Cholec80, SPRMamba achieves state-of-the-art performance (87.64% accuracy on ESD385, +1.0% over prior methods), demonstrating robust generalizability across surgical workflows. This advancement bridges the gap between computational efficiency and temporal sensitivity, offering a transformative tool for intraoperative guidance and skill assessment in ESD surgery. The code is accessible at https://github.com/Zxnyyyyy/SPRMamba.

MRI is an indispensable clinical tool, offering a rich variety of tissue contrasts to support broad diagnostic and research applications. Clinical exams routinely acquire multiple structural sequences that provide complementary information for differential diagnosis, while research protocols often incorporate advanced functional, diffusion, spectroscopic, and relaxometry sequences to capture multidimensional insights into tissue structure and composition. However, these capabilities come at the cost of prolonged scan times, which reduce patient throughput, increase susceptibility to motion artifacts, and may require trade-offs in image quality or diagnostic scope. Over the last two decades, advances in image reconstruction algorithms--alongside improvements in hardware and pulse sequence design--have made it possible to accelerate acquisitions while preserving diagnostic quality. Central to this progress is the ability to incorporate prior information to regularize the solutions to the reconstruction problem. In this tutorial, we overview the basics of MRI reconstruction and highlight state-of-the-art approaches, beginning with classical methods that rely on explicit hand-crafted priors, and then turning to deep learning methods that leverage a combination of learned and crafted priors to further push the performance envelope. We also explore the translational aspects and eventual clinical implications of these methods. We conclude by discussing future directions to address remaining challenges in MRI reconstruction. The tutorial is accompanied by a Python toolbox (https://github.com/tutorial-MRI-recon/tutorial) to demonstrate select methods discussed in the article.

The observations in many applications consist of counts of discrete events, such as photons hitting a detector, which cannot be effectively modeled using an additive bounded or Gaussian noise model, and instead require a Poisson noise model. As a result, accurate reconstruction of a spatially or temporally distributed phenomenon (f*) from Poisson data (y) cannot be effectively accomplished by minimizing a conventional penalized least-squares objective function. The problem addressed in this paper is the estimation of f* from y in an inverse problem setting, where (a) the number of unknowns may potentially be larger than the number of observations and (b) f* admits a sparse approximation. The optimization formulation considered in this paper uses a penalized negative Poisson log-likelihood objective function with nonnegativity constraints (since Poisson intensities are naturally nonnegative). In particular, the proposed approach incorporates key ideas of using separable quadratic approximations to the objective function at each iteration and penalization terms related to l1 norms of coefficient vectors, total variation seminorms, and partition-based multiscale estimation methods.

Hyperthermia (HT) in combination with radio- and/or chemotherapy has become an accepted cancer treatment for distinct solid tumour entities. In HT, tumour tissue is exogenously heated to temperatures between 39 and 43 ^circC for 60 minutes. Temperature monitoring can be performed non-invasively using dynamic magnetic resonance imaging (MRI). However, the slow nature of MRI leads to motion artefacts in the images due to the movements of patients during image acquisition. By discarding parts of the data, the speed of the acquisition can be increased - known as undersampling. However, due to the invalidation of the Nyquist criterion, the acquired images might be blurry and can also produce aliasing artefacts. The aim of this work was, therefore, to reconstruct highly undersampled MR thermometry acquisitions with better resolution and with fewer artefacts compared to conventional methods. The use of deep learning in the medical field has emerged in recent times, and various studies have shown that deep learning has the potential to solve inverse problems such as MR image reconstruction. However, most of the published work only focuses on the magnitude images, while the phase images are ignored, which are fundamental requirements for MR thermometry. This work, for the first time, presents deep learning-based solutions for reconstructing undersampled MR thermometry data. Two different deep learning models have been employed here, the Fourier Primal-Dual network and the Fourier Primal-Dual UNet, to reconstruct highly undersampled complex images of MR thermometry. The method reduced the temperature difference between the undersampled MRIs and the fully sampled MRIs from 1.3 ^circC to 0.6 ^circC in full volume and 0.49 ^circC to 0.06 ^circC in the tumour region for an acceleration factor of 10.

Recently, Ultra-High Field MRI (UHF-MRI) has become more available and one of the best tools to study the brain. One common step in quantitative neuroimaging is to segment the brain into several regions, which has been done using software packages like FreeSurfer , FastSurferVINN or SynthSeg. However, the differences between UHF-MRI and 1.5T or 3T images are such that the automatic segmentation techniques optimized at these field strengths usually produce unsatisfactory segmentation results for UHF images. Thus, it has been particularly challenging to perform region-based quantitative analyses as typically done with 1.5-3T data, underscoring the crucial need for developing new automatic segmentation techniques designed to handle UHF images. Hence, we propose a novel Deep Learning (DL)-based segmentation technique called GOUHFI: Generalized and Optimized segmentation tool for Ultra-High Field Images, designed to segment UHF images of various contrasts and resolutions. For training, we used a total of 206 label maps from datasets acquired at 3T, 7T and 9.4T. In contrast to most DL strategies, we used a domain randomization approach, where synthetic images were used to train a 3D U-Net. GOUHFI was tested on seven different datasets and compared to existing techniques like FastSurferVINN,SynthSeg and CEREBRUM-7T. GOUHFI was able to segment the six contrasts and seven resolutions tested at 3T, 7T and 9.4T. Average Dice scores of 0.90, 0.90 and 0.93 were computed against the ground truth segmentations at 3T, 7T and 9.4T, respectively. Ultimately, GOUHFI is a promising new segmentation tool, being the first of its kind proposing a contrast- and resolution-agnostic alternative for UHF-MRI without requiring fine-tuning or retraining, making it the forthcoming alternative for neuroscientists working with UHF-MRI or even lower field strengths.

Computational sensing strategies often suffer from calibration errors in the physical implementation of their ideal sensing models. Such uncertainties are typically addressed by using multiple, accurately chosen training signals to recover the missing information on the sensing model, an approach that can be resource-consuming and cumbersome. Conversely, blind calibration does not employ any training signal, but corresponds to a bilinear inverse problem whose algorithmic solution is an open issue. We here address blind calibration as a non-convex problem for linear random sensing models, in which we aim to recover an unknown signal from its projections on sub-Gaussian random vectors, each subject to an unknown positive multiplicative factor (or gain). To solve this optimisation problem we resort to projected gradient descent starting from a suitable, carefully chosen initialisation point. An analysis of this algorithm allows us to show that it converges to the exact solution provided a sample complexity requirement is met, i.e., relating convergence to the amount of information collected during the sensing process. Interestingly, we show that this requirement grows linearly (up to log factors) in the number of unknowns of the problem. This sample complexity is found both in absence of prior information, as well as when subspace priors are available for both the signal and gains, allowing a further reduction of the number of observations required for our recovery guarantees to hold. Moreover, in the presence of noise we show how our descent algorithm yields a solution whose accuracy degrades gracefully with the amount of noise affecting the measurements. Finally, we present some numerical experiments in an imaging context, where our algorithm allows for a simple solution to blind calibration of the gains in a sensor array.

Off-resonance artifacts in magnetic resonance imaging (MRI) are visual distortions that occur when the actual resonant frequencies of spins within the imaging volume differ from the expected frequencies used to encode spatial information. These discrepancies can be caused by a variety of factors, including magnetic field inhomogeneities, chemical shifts, or susceptibility differences within the tissues. Such artifacts can manifest as blurring, ghosting, or misregistration of the reconstructed image, and they often compromise its diagnostic quality. We propose to resolve these artifacts by lifting the 2D MRI reconstruction problem to 3D, introducing an additional "spectral" dimension to model this off-resonance. Our approach is inspired by recent progress in modeling radiance fields, and is capable of reconstructing both static and dynamic MR images as well as separating fat and water, which is of independent clinical interest. We demonstrate our approach in the context of PROPELLER (Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction) MRI acquisitions, which are popular for their robustness to motion artifacts. Our method operates in a few minutes on a single GPU, and to our knowledge is the first to correct for chemical shift in gradient echo PROPELLER MRI reconstruction without additional measurements or pretraining data.

In metrology, Fisher information is an important metric that quantifies the precision that can be achieved in a measurement. For optical measurements using coherent light it has been shown that Fisher information can be expressed simply using the scattering matrix of the system. Fisher information can be maximized over the input modes to achieve maximum information states, which produce optimally precise estimates for a parameter when the system is limited by photon noise. Here, we extend this approach to multiparameter estimation, in which case Fisher information takes the form of a matrix. We consider several scalar functions of the Fisher matrix to optimize the precision in multiple parameters at the same time. We also consider strategies for dealing with nuisance parameters, which can degrade the achievable precision of other parameters but are not of interest to measure. We corroborate our findings numerically using a scattering system of 2D coupled dipoles.

In biomedical imaging analysis, the dichotomy between 2D and 3D data presents a significant challenge. While 3D volumes offer superior real-world applicability, they are less available for each modality and not easy to train in large scale, whereas 2D samples are abundant but less comprehensive. This paper introduces the Cross-D Conv operation, a novel approach that bridges the dimensional gap by learning the phase shifting in the Fourier domain. Our method enables seamless weight transfer between 2D and 3D convolution operations, effectively facilitating cross-dimensional learning. The proposed architecture leverages the abundance of 2D training data to enhance 3D model performance, offering a practical solution to the multimodal data scarcity challenge in 3D medical model pretraining. Experimental validation on the RadImagenet (2D) and multimodal (3D) sets demonstrates that our approach achieves comparable or superior performance in feature quality assessment comparable to conventional methods. The enhanced convolution operation presents new opportunities for developing efficient classification and segmentation models in medical imaging. This work represents an advancement in cross-dimensional and multi-modal medical image analysis, offering a robust framework for utilizing 2D priors in 3D model pretraining or vice versa while maintaining computational efficiency.

Magnetization transfer contrast magnetic resonance fingerprinting (MTC-MRF) is a novel quantitative imaging technique that simultaneously measures several tissue parameters of semisolid macromolecule and free bulk water. In this study, we propose an Only-Train-Once MR fingerprinting (OTOM) framework that estimates the free bulk water and MTC tissue parameters from MR fingerprints regardless of MRF schedule, thereby avoiding time-consuming process such as generation of training dataset and network training according to each MRF schedule. A recurrent neural network is designed to cope with two types of variants of MRF schedules: 1) various lengths and 2) various patterns. Experiments on digital phantoms and in vivo data demonstrate that our approach can achieve accurate quantification for the water and MTC parameters with multiple MRF schedules. Moreover, the proposed method is in excellent agreement with the conventional deep learning and fitting methods. The flexible OTOM framework could be an efficient tissue quantification tool for various MRF protocols.

Echocardiography has been a prominent tool for the diagnosis of cardiac disease. However, these diagnoses can be heavily impeded by poor image quality. Acoustic clutter emerges due to multipath reflections imposed by layers of skin, subcutaneous fat, and intercostal muscle between the transducer and heart. As a result, haze and other noise artifacts pose a real challenge to cardiac ultrasound imaging. In many cases, especially with difficult-to-image patients such as patients with obesity, a diagnosis from B-Mode ultrasound imaging is effectively rendered unusable, forcing sonographers to resort to contrast-enhanced ultrasound examinations or refer patients to other imaging modalities. Tissue harmonic imaging has been a popular approach to combat haze, but in severe cases is still heavily impacted by haze. Alternatively, denoising algorithms are typically unable to remove highly structured and correlated noise, such as haze. It remains a challenge to accurately describe the statistical properties of structured haze, and develop an inference method to subsequently remove it. Diffusion models have emerged as powerful generative models and have shown their effectiveness in a variety of inverse problems. In this work, we present a joint posterior sampling framework that combines two separate diffusion models to model the distribution of both clean ultrasound and haze in an unsupervised manner. Furthermore, we demonstrate techniques for effectively training diffusion models on radio-frequency ultrasound data and highlight the advantages over image data. Experiments on both in-vitro and in-vivo cardiac datasets show that the proposed dehazing method effectively removes haze while preserving signals from weakly reflected tissue.

High-resolution (HR) magnetic resonance imaging (MRI) is crucial for many clinical and research applications. However, achieving it remains costly and constrained by technical trade-offs and experimental limitations. Super-resolution (SR) presents a promising computational approach to overcome these challenges by generating HR images from more affordable low-resolution (LR) scans, potentially improving diagnostic accuracy and efficiency without requiring additional hardware. This survey reviews recent advances in MRI SR techniques, with a focus on deep learning (DL) approaches. It examines DL-based MRI SR methods from the perspectives of computer vision, computational imaging, inverse problems, and MR physics, covering theoretical foundations, architectural designs, learning strategies, benchmark datasets, and performance metrics. We propose a systematic taxonomy to categorize these methods and present an in-depth study of both established and emerging SR techniques applicable to MRI, considering unique challenges in clinical and research contexts. We also highlight open challenges and directions that the community needs to address. Additionally, we provide a collection of essential open-access resources, tools, and tutorials, available on our GitHub: https://github.com/mkhateri/Awesome-MRI-Super-Resolution. IEEE keywords: MRI, Super-Resolution, Deep Learning, Computational Imaging, Inverse Problem, Survey.

The out-of-band energy loss caused by in-built color filters significantly degrades the signal-to-noise ratio and the dynamic range of conventional image sensors, which has restricted the attempt to develop ultrahigh-density imaging devices by merely shrinking the pixel size. This issue will be more serious for security cameras which need to collect visible (VIS) light and near-infrared (NIR) photons as well. The existing solutions mostly explore complex photonic nanostructures, which are often too complicated for production. In this work, we demonstrate a pixel-scale spectral router utilizing two-dimensional (2D) Si3N4 Mie scattering metagratings that can spatially divide NIR (850 nm) and VIS (400-700 nm) light to different pixels at high efficiencies. It has a minimum feature size larger than 360 nm, highly promising for massive production. Compared with the traditional filter design, our router can gain about 42% and 30% signal enhancement for NIR and VIS band, respectively. We show that it also has good polarization insensitivity and incident angle tolerance. The NIR-VIS simultaneous imaging is inspected without any complex reconstruction algorithm. Mode analysis indicates that the multipolar scattering of our Mie-type metagratings provides the necessary degrees of freedom to spatially optimize the routing functions for broadband photons.

X-ray angiography is widely used in cardiac interventions to visualize coronary vessels, assess integrity, detect stenoses and guide treatment. We propose a framework for reconstructing 3D vessel trees from biplanar X-ray images which are extracted from two X-ray videos captured at different C-arm angles. The proposed framework consists of three main components: image segmentation, motion phase matching, and 3D reconstruction. An automatic video segmentation method for X-ray angiography to enable semantic segmentation for image segmentation and motion phase matching. The goal of the motion phase matching is to identify a pair of X-ray images that correspond to a similar respiratory and cardiac motion phase to reduce errors in 3D reconstruction. This is achieved by tracking a stationary object such as a catheter or lead within the X-ray video. The semantic segmentation approach assigns different labels to different object classes enabling accurate differentiation between blood vessels, balloons, and catheters. Once a suitable image pair is selected, key anatomical landmarks (vessel branching points and endpoints) are matched between the two views using a heuristic method that minimizes reconstruction errors. This is followed by a novel geometric reconstruction algorithm to generate the 3D vessel tree. The algorithm computes the 3D vessel centrelines by determining the intersection of two 3D surfaces. Compared to traditional methods based on epipolar constraints, the proposed approach simplifies there construction workflow and improves overall accuracy. We trained and validated our segmentation method on 62 X-ray angiography video sequences. On the test set, our method achieved a segmentation accuracy of 0.703. The 3D reconstruction framework was validated by measuring the reconstruction error of key anatomical landmarks, achieving a reprojection errors of 0.62mm +/- 0.38mm.

High dynamic range (HDR) imaging involves capturing a series of frames of the same scene, each with different exposure settings, to broaden the dynamic range of light. This can be achieved through burst capturing or using staggered HDR sensors that capture long and short exposures simultaneously in the camera image signal processor (ISP). Within camera ISP pipeline, illuminant estimation is a crucial step aiming to estimate the color of the global illuminant in the scene. This estimation is used in camera ISP white-balance module to remove undesirable color cast in the final image. Despite the multiple frames captured in the HDR pipeline, conventional illuminant estimation methods often rely only on a single frame of the scene. In this paper, we explore leveraging information from frames captured with different exposure times. Specifically, we introduce a simple feature extracted from dual-exposure images to guide illuminant estimators, referred to as the dual-exposure feature (DEF). To validate the efficiency of DEF, we employed two illuminant estimators using the proposed DEF: 1) a multilayer perceptron network (MLP), referred to as exposure-based MLP (EMLP), and 2) a modified version of the convolutional color constancy (CCC) to integrate our DEF, that we call ECCC. Both EMLP and ECCC achieve promising results, in some cases surpassing prior methods that require hundreds of thousands or millions of parameters, with only a few hundred parameters for EMLP and a few thousand parameters for ECCC.

AI is revolutionizing MRI along the acquisition and processing chain. Advanced AI frameworks have been developed to apply AI in various successive tasks, such as image reconstruction, quantitative parameter map estimation, and image segmentation. Existing frameworks are often designed to perform tasks independently or are focused on specific models or datasets, limiting generalization. We introduce ATOMMIC, an open-source toolbox that streamlines AI applications for accelerated MRI reconstruction and analysis. ATOMMIC implements several tasks using DL networks and enables MultiTask Learning (MTL) to perform related tasks integrated, targeting generalization in the MRI domain. We first review the current state of AI frameworks for MRI through a comprehensive literature search and by parsing 12,479 GitHub repositories. We benchmark 25 DL models on eight publicly available datasets to present distinct applications of ATOMMIC on accelerated MRI reconstruction, image segmentation, quantitative parameter map estimation, and joint accelerated MRI reconstruction and image segmentation utilizing MTL. Our findings demonstrate that ATOMMIC is the only MTL framework with harmonized complex-valued and real-valued data support. Evaluations on single tasks show that physics-based models, which enforce data consistency by leveraging the physical properties of MRI, outperform other models in reconstructing highly accelerated acquisitions. Physics-based models that produce high reconstruction quality can accurately estimate quantitative parameter maps. When high-performing reconstruction models are combined with robust segmentation networks utilizing MTL, performance is improved in both tasks. ATOMMIC facilitates MRI reconstruction and analysis by standardizing workflows, enhancing data interoperability, integrating unique features like MTL, and effectively benchmarking DL models.

3D Gaussian Splatting (3D-GS) has demonstrated exceptional capabilities in 3D scene reconstruction and novel view synthesis. However, its training heavily depends on high-quality, sharp images and accurate camera poses. Fulfilling these requirements can be challenging in non-ideal real-world scenarios, where motion-blurred images are commonly encountered in high-speed moving cameras or low-light environments that require long exposure times. To address these challenges, we introduce Event Stream Assisted Gaussian Splatting (EvaGaussians), a novel approach that integrates event streams captured by an event camera to assist in reconstructing high-quality 3D-GS from blurry images. Capitalizing on the high temporal resolution and dynamic range offered by the event camera, we leverage the event streams to explicitly model the formation process of motion-blurred images and guide the deblurring reconstruction of 3D-GS. By jointly optimizing the 3D-GS parameters and recovering camera motion trajectories during the exposure time, our method can robustly facilitate the acquisition of high-fidelity novel views with intricate texture details. We comprehensively evaluated our method and compared it with previous state-of-the-art deblurring rendering methods. Both qualitative and quantitative comparisons demonstrate that our method surpasses existing techniques in restoring fine details from blurry images and producing high-fidelity novel views.

Clinicians are often very sceptical about applying automatic image processing approaches, especially deep learning based methods, in practice. One main reason for this is the black-box nature of these approaches and the inherent problem of missing insights of the automatically derived decisions. In order to increase trust in these methods, this paper presents approaches that help to interpret and explain the results of deep learning algorithms by depicting the anatomical areas which influence the decision of the algorithm most. Moreover, this research presents a unified framework, TorchEsegeta, for applying various interpretability and explainability techniques for deep learning models and generate visual interpretations and explanations for clinicians to corroborate their clinical findings. In addition, this will aid in gaining confidence in such methods. The framework builds on existing interpretability and explainability techniques that are currently focusing on classification models, extending them to segmentation tasks. In addition, these methods have been adapted to 3D models for volumetric analysis. The proposed framework provides methods to quantitatively compare visual explanations using infidelity and sensitivity metrics. This framework can be used by data scientists to perform post-hoc interpretations and explanations of their models, develop more explainable tools and present the findings to clinicians to increase their faith in such models. The proposed framework was evaluated based on a use case scenario of vessel segmentation models trained on Time-of-fight (TOF) Magnetic Resonance Angiogram (MRA) images of the human brain. Quantitative and qualitative results of a comparative study of different models and interpretability methods are presented. Furthermore, this paper provides an extensive overview of several existing interpretability and explainability methods.

In Ultrasound Localization Microscopy (ULM),achieving high-resolution images relies on the precise localization of contrast agent particles across consecutive beam-formed frames. However, our study uncovers an enormous potential: The process of delay-and-sum beamforming leads to an irreversible reduction of Radio-Frequency (RF) data, while its implications for localization remain largely unexplored. The rich contextual information embedded within RF wavefronts, including their hyperbolic shape and phase, offers great promise for guiding Deep Neural Networks (DNNs) in challenging localization scenarios. To fully exploit this data, we propose to directly localize scatterers in RF signals. Our approach involves a custom super-resolution DNN using learned feature channel shuffling and a novel semi-global convolutional sampling block tailored for reliable and accurate wavefront localization. Additionally, we introduce a geometric point transformation that facilitates seamless mapping between RF and B-mode coordinate space. To understand the impact of beamforming on ULM, we validate the effectiveness of our method by conducting an extensive comparison with State-Of-The-Art (SOTA) techniques. We present the inaugural in vivo results from an RF-trained DNN, highlighting its real-world practicality. Our findings show that RF-ULM bridges the domain gap between synthetic and real datasets, offering a considerable advantage in terms of precision and complexity. To enable the broader research community to benefit from our findings, our code and the associated SOTA methods are made available at https://github.com/hahnec/rf-ulm.

Dynamic radiance field reconstruction methods aim to model the time-varying structure and appearance of a dynamic scene. Existing methods, however, assume that accurate camera poses can be reliably estimated by Structure from Motion (SfM) algorithms. These methods, thus, are unreliable as SfM algorithms often fail or produce erroneous poses on challenging videos with highly dynamic objects, poorly textured surfaces, and rotating camera motion. We address this robustness issue by jointly estimating the static and dynamic radiance fields along with the camera parameters (poses and focal length). We demonstrate the robustness of our approach via extensive quantitative and qualitative experiments. Our results show favorable performance over the state-of-the-art dynamic view synthesis methods.

Reconstructing medical images from partial measurements is an important inverse problem in Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Existing solutions based on machine learning typically train a model to directly map measurements to medical images, leveraging a training dataset of paired images and measurements. These measurements are typically synthesized from images using a fixed physical model of the measurement process, which hinders the generalization capability of models to unknown measurement processes. To address this issue, we propose a fully unsupervised technique for inverse problem solving, leveraging the recently introduced score-based generative models. Specifically, we first train a score-based generative model on medical images to capture their prior distribution. Given measurements and a physical model of the measurement process at test time, we introduce a sampling method to reconstruct an image consistent with both the prior and the observed measurements. Our method does not assume a fixed measurement process during training, and can thus be flexibly adapted to different measurement processes at test time. Empirically, we observe comparable or better performance to supervised learning techniques in several medical imaging tasks in CT and MRI, while demonstrating significantly better generalization to unknown measurement processes.

Magnetic resonance imaging (MRI) is a common and life-saving medical imaging technique. However, acquiring high signal-to-noise ratio MRI scans requires long scan times, resulting in increased costs and patient discomfort, and decreased throughput. Thus, there is great interest in denoising MRI scans, especially for the subtype of diffusion MRI scans that are severely SNR-limited. While most prior MRI denoising methods are supervised in nature, acquiring supervised training datasets for the multitude of anatomies, MRI scanners, and scan parameters proves impractical. Here, we propose Denoising Diffusion Models for Denoising Diffusion MRI (DDM^2), a self-supervised denoising method for MRI denoising using diffusion denoising generative models. Our three-stage framework integrates statistic-based denoising theory into diffusion models and performs denoising through conditional generation. During inference, we represent input noisy measurements as a sample from an intermediate posterior distribution within the diffusion Markov chain. We conduct experiments on 4 real-world in-vivo diffusion MRI datasets and show that our DDM^2 demonstrates superior denoising performances ascertained with clinically-relevant visual qualitative and quantitative metrics.

Radiance fields have emerged as powerful tools for 3D scene reconstruction. However, casual capture remains challenging due to the narrow field of view of perspective cameras, which limits viewpoint coverage and feature correspondences necessary for reliable camera calibration and reconstruction. While commercially available 360^circ cameras offer significantly broader coverage than perspective cameras for the same capture effort, existing 360^circ reconstruction methods require special capture protocols and pre-processing steps that undermine the promise of radiance fields: effortless workflows to capture and reconstruct 3D scenes. We propose a practical pipeline for reconstructing 3D scenes directly from raw 360^circ camera captures. We require no special capture protocols or pre-processing, and exhibit robustness to a prevalent source of reconstruction errors: the human operator that is visible in all 360^circ imagery. To facilitate evaluation, we introduce a multi-tiered dataset of scenes captured as raw dual-fisheye images, establishing a benchmark for robust casual 360^circ reconstruction. Our method significantly outperforms not only vanilla 3DGS for 360^circ cameras but also robust perspective baselines when perspective cameras are simulated from the same capture, demonstrating the advantages of 360^circ capture for casual reconstruction. Additional results are available at: https://theialab.github.io/fullcircle

The field of image generation has made significant progress thanks to the introduction of Diffusion Models, which learn to progressively reverse a given image corruption. Recently, a few studies introduced alternative ways of corrupting images in Diffusion Models, with an emphasis on blurring. However, these studies are purely empirical and it remains unclear what is the optimal procedure for corrupting an image. In this work, we hypothesize that the optimal procedure minimizes the length of the path taken when corrupting an image towards a given final state. We propose the Fisher metric for the path length, measured in the space of probability distributions. We compute the shortest path according to this metric, and we show that it corresponds to a combination of image sharpening, rather than blurring, and noise deblurring. While the corruption was chosen arbitrarily in previous work, our Shortest Path Diffusion (SPD) determines uniquely the entire spatiotemporal structure of the corruption. We show that SPD improves on strong baselines without any hyperparameter tuning, and outperforms all previous Diffusion Models based on image blurring. Furthermore, any small deviation from the shortest path leads to worse performance, suggesting that SPD provides the optimal procedure to corrupt images. Our work sheds new light on observations made in recent works and provides a new approach to improve diffusion models on images and other types of data.

High dynamic range (HDR) images capture much more intensity levels than standard ones. Current methods predominantly generate HDR images from 8-bit low dynamic range (LDR) sRGB images that have been degraded by the camera processing pipeline. However, it becomes a formidable task to retrieve extremely high dynamic range scenes from such limited bit-depth data. Unlike existing methods, the core idea of this work is to incorporate more informative Raw sensor data to generate HDR images, aiming to recover scene information in hard regions (the darkest and brightest areas of an HDR scene). To this end, we propose a model tailor-made for Raw images, harnessing the unique features of Raw data to facilitate the Raw-to-HDR mapping. Specifically, we learn exposure masks to separate the hard and easy regions of a high dynamic scene. Then, we introduce two important guidances, dual intensity guidance, which guides less informative channels with more informative ones, and global spatial guidance, which extrapolates scene specifics over an extended spatial domain. To verify our Raw-to-HDR approach, we collect a large Raw/HDR paired dataset for both training and testing. Our empirical evaluations validate the superiority of the proposed Raw-to-HDR reconstruction model, as well as our newly captured dataset in the experiments.

Neural vocoders have recently advanced waveform generation, yielding natural and expressive audio. Among these approaches, iSTFT-based vocoders have recently gained attention. They predict a complex-valued spectrogram and then synthesize the waveform via iSTFT, thereby avoiding learned upsampling stages that can increase computational cost. However, current approaches use real-valued networks that process the real and imaginary parts independently. This separation limits their ability to capture the inherent structure of complex spectrograms. We present ComVo, a Complex-valued neural Vocoder whose generator and discriminator use native complex arithmetic. This enables an adversarial training framework that provides structured feedback in complex-valued representations. To guide phase transformations in a structured manner, we introduce phase quantization, which discretizes phase values and regularizes the training process. Finally, we propose a block-matrix computation scheme to improve training efficiency by reducing redundant operations. Experiments demonstrate that ComVo achieves higher synthesis quality than comparable real-valued baselines, and that its block-matrix scheme reduces training time by 25%. Audio samples and code are available at https://hs-oh-prml.github.io/ComVo/.

X-ray is widely applied for transmission imaging due to its stronger penetration than natural light. When rendering novel view X-ray projections, existing methods mainly based on NeRF suffer from long training time and slow inference speed. In this paper, we propose a 3D Gaussian splatting-based framework, namely X-Gaussian, for X-ray novel view synthesis. Firstly, we redesign a radiative Gaussian point cloud model inspired by the isotropic nature of X-ray imaging. Our model excludes the influence of view direction when learning to predict the radiation intensity of 3D points. Based on this model, we develop a Differentiable Radiative Rasterization (DRR) with CUDA implementation. Secondly, we customize an Angle-pose Cuboid Uniform Initialization (ACUI) strategy that directly uses the parameters of the X-ray scanner to compute the camera information and then uniformly samples point positions within a cuboid enclosing the scanned object. Experiments show that our X-Gaussian outperforms state-of-the-art methods by 6.5 dB while enjoying less than 15% training time and over 73x inference speed. The application on sparse-view CT reconstruction also reveals the practical values of our method. Code and models will be publicly available at https://github.com/caiyuanhao1998/X-Gaussian . A video demo of the training process visualization is at https://www.youtube.com/watch?v=gDVf_Ngeghg .

Regularisation is commonly used in iterative methods for solving imaging inverse problems. Many algorithms involve the evaluation of the proximal operator of the regularisation term in every iteration, leading to a significant computational overhead since such evaluation can be costly. In this context, the ProxSkip algorithm, recently proposed for federated learning purposes, emerges as an solution. It randomly skips regularisation steps, reducing the computational time of an iterative algorithm without affecting its convergence. Here we explore for the first time the efficacy of ProxSkip to a variety of imaging inverse problems and we also propose a novel PDHGSkip version. Extensive numerical results highlight the potential of these methods to accelerate computations while maintaining high-quality reconstructions.

Ultrasound Localization Microscopy (ULM) enables imaging of vascular structures in the micrometer range by accumulating contrast agent particle locations over time. Precise and efficient target localization accuracy remains an active research topic in the ULM field to further push the boundaries of this promising medical imaging technology. Existing work incorporates Delay-And-Sum (DAS) beamforming into particle localization pipelines, which ultimately determines the ULM image resolution capability. In this paper we propose to feed unprocessed Radio-Frequency (RF) data into a super-resolution network while bypassing DAS beamforming and its limitations. To facilitate this, we demonstrate label projection and inverse point transformation between B-mode and RF coordinate space as required by our approach. We assess our method against state-of-the-art techniques based on a public dataset featuring in silico and in vivo data. Results from our RF-trained network suggest that excluding DAS beamforming offers a great potential to optimize on the ULM resolution performance.

One of the key impediments for developing and assessing robust medical imaging algorithms is limited access to large-scale datasets with suitable annotations. Synthetic data generated with plausible physical and biological constraints may address some of these data limitations. We propose the use of physics simulations to generate synthetic images with pixel-level segmentation annotations, which are notoriously difficult to obtain. Specifically, we apply this approach to breast imaging analysis and release T-SYNTH, a large-scale open-source dataset of paired 2D digital mammography (DM) and 3D digital breast tomosynthesis (DBT) images. Our initial experimental results indicate that T-SYNTH images show promise for augmenting limited real patient datasets for detection tasks in DM and DBT. Our data and code are publicly available at https://github.com/DIDSR/tsynth-release.

Computational microscopy, in which hardware and algorithms of an imaging system are jointly designed, shows promise for making imaging systems that cost less, perform more robustly, and collect new types of information. Often, the performance of computational imaging systems, especially those that incorporate machine learning, is sample-dependent. Thus, standardized datasets are an essential tool for comparing the performance of different approaches. Here, we introduce the Berkeley Single Cell Computational Microscopy (BSCCM) dataset, which contains over ~12,000,000 images of 400,000 of individual white blood cells. The dataset contains images captured with multiple illumination patterns on an LED array microscope and fluorescent measurements of the abundance of surface proteins that mark different cell types. We hope this dataset will provide a valuable resource for the development and testing of new algorithms in computational microscopy and computer vision with practical biomedical applications.

Single-image HDR reconstruction aims to recover high dynamic range radiance from a single low dynamic range (LDR) input, but remains highly ill-posed due to detail saturation in over-exposed regions and noise amplification in under-exposed areas. While recent diffusion-based approaches offer powerful generative priors, they often overlook the exposure-dependent nature of the degradation and incur substantial computational costs from iterative sampling. To address these challenges, we propose ExpoCM, a novel one-step generative HDR reconstruction framework that reformulates HDR reconstruction as a Probability Flow ODE (PF-ODE) and constructs exposure-aware consistency trajectories via exposure-dependent perturbations. Specifically, a soft exposure mask is first constructed to separate the LDR image into over-, under-, and well-exposed regions. Based on this partition, region-conditioned consistency trajectories are designed to hallucinate saturated details, suppress noise in dark regions, and preserve reliable structures within a single, distillation-free inference step. To further enhance perceptual quality, we introduce an Exposure-guided Luminance-Chromaticity Loss in the CIE~L^*a^*b^* space, which assigns exposure-aware weights to luminance and chromaticity components, effectively mitigating brightness bias and color drift. Extensive experiments on the HDR-REAL, HDR-EYE, and AIM2025 benchmarks demonstrate that ExpoCM achieves state-of-the-art fidelity and perceptual accuracy, while enabling over 400times and 20times faster inference compared to DDPM (1000 steps) and DDIM (50 steps), respectively.

Machine learning-based computer-generated holography (ML-CGH) has advanced rapidly in recent years, yet progress is constrained by the limited availability of high-quality, large-scale hologram datasets. To address this, we present KOREATECH-CGH, a publicly available dataset comprising 6,000 pairs of RGB-D images and complex holograms across resolutions ranging from 256*256 to 2048*2048, with depth ranges extending to the theoretical limits of the angular spectrum method for wide 3D scene coverage. To improve hologram quality at large depth ranges, we introduce amplitude projection, a post-processing technique that replaces amplitude components of hologram wavefields at each depth layer while preserving phase. This approach enhances reconstruction fidelity, achieving 27.01 dB PSNR and 0.87 SSIM, surpassing a recent optimized silhouette-masking layer-based method by 2.03 dB and 0.04 SSIM, respectively. We further validate the utility of KOREATECH-CGH through experiments on hologram generation and super-resolution using state-of-the-art ML models, confirming its applicability for training and evaluating next-generation ML-CGH systems.

We present a generative framework for inverse design of five-layer transmissive Huygens' metasurfaces (HMSs), addressing a longstanding challenge in achieving full-phase, high-efficiency unit cell designs with minimal full-wave simulations. The key to achieving this is our reliance on the field-based semianalytical (SA) scheme developed in Part I of this paper, which allows rapid and highly effective synthesis of such multilayer composites, however with limited accuracy. To overcome the prohibitive data demands of traditional pipelines, we employ Mamba, a selective state space model well suited for long-range sequence modeling as the backbone of our learning framework. A bidirectional Mamba (Bi-Mamba) forward surrogate is first trained on SA-generated data and subsequently fine-tuned with full-wave CST samples. An ablation over a 1080-sample CST pool shows that as few as 270 full-wave calibration samples suffice to reach near-CST-level agreement at a fraction of the simulation cost. An autoregressive Mamba inverse generator is subsequently trained on surrogate-augmented data, treating unit-cell synthesis as a sequential generation task. The resulting one-to-many generative model produces diverse unit cell geometries conditioned on target scattering responses. It achieves CST-validated designs with field transmission magnitude 0.9 across the full 0-2π phase range at 20 GHz. Moreover, a CST-calibrated surrogate trained to accurately predict frequency responses (18-22 GHz) enables functional post-selection of inverse generated designs. Together, the hybrid SA-generative methodology in this two-part compilation establishes a scalable and data-efficient solution for multilayer HMS synthesis, with natural extensions toward broadband, oblique-incidence, and higher-dimensional electromagnetic inverse-design problems.

Significant progress has been made in photo-realistic scene reconstruction over recent years. Various disparate efforts have enabled capabilities such as multi-appearance or large-scale modeling; however, there lacks a welldesigned dataset that can evaluate the holistic progress of scene reconstruction. We introduce a collection of imagery of the Johns Hopkins Homewood Campus, acquired at different seasons, times of day, in multiple elevations, and across a large scale. We perform a multi-stage calibration process, which efficiently recover camera parameters from phone and drone cameras. This dataset can enable researchers to rigorously explore challenges in unconstrained settings, including effects of inconsistent illumination, reconstruction from large scale and from significantly different perspectives, etc.

In image processing, the amount of data to be processed grows rapidly, in particular when imaging methods yield images of more than two dimensions or time series of images. Thus, efficient processing is a challenge, as data sizes may push even supercomputers to their limits. Quantum image processing promises to encode images with logarithmically less qubits than classical pixels in the image. In theory, this is a huge progress, but so far not many experiments have been conducted in practice, in particular on real backends. Often, the precise conversion of classical data to quantum states, the exact implementation, and the interpretation of the measurements in the classical context are challenging. We investigate these practical questions in this paper. In particular, we study the feasibility of the Flexible Representation of Quantum Images (FRQI). Furthermore, we check experimentally what is the limit in the current noisy intermediate-scale quantum era, i.e. up to which image size an image can be encoded, both on simulators and on real backends. Finally, we propose a method for simplifying the circuits needed for the FRQI. With our alteration, the number of gates needed, especially of the error-prone controlled-NOT gates, can be reduced. As a consequence, the size of manageable images increases.

Compressed Sensing (CS) significantly speeds up Magnetic Resonance Image (MRI) processing and achieves accurate MRI reconstruction from under-sampled k-space data. According to the current research, there are still several problems with dynamic MRI k-space reconstruction based on CS. 1) There are differences between the Fourier domain and the Image domain, and the differences between MRI processing of different domains need to be considered. 2) As three-dimensional data, dynamic MRI has its spatial-temporal characteristics, which need to calculate the difference and consistency of surface textures while preserving structural integrity and uniqueness. 3) Dynamic MRI reconstruction is time-consuming and computationally resource-dependent. In this paper, we propose a novel robust low-rank dynamic MRI reconstruction optimization model via highly under-sampled and Discrete Fourier Transform (DFT) called the Robust Depth Linear Error Decomposition Model (RDLEDM). Our method mainly includes linear decomposition, double Total Variation (TV), and double Nuclear Norm (NN) regularizations. By adding linear image domain error analysis, the noise is reduced after under-sampled and DFT processing, and the anti-interference ability of the algorithm is enhanced. Double TV and NN regularizations can utilize both spatial-temporal characteristics and explore the complementary relationship between different dimensions in dynamic MRI sequences. In addition, Due to the non-smoothness and non-convexity of TV and NN terms, it is difficult to optimize the unified objective model. To address this issue, we utilize a fast algorithm by solving a primal-dual form of the original problem. Compared with five state-of-the-art methods, extensive experiments on dynamic MRI data demonstrate the superior performance of the proposed method in terms of both reconstruction accuracy and time complexity.

Multiple-input-multiple-output (MIMO) millimeter-wave (mmWave) sensors for synthetic aperture radar (SAR) and inverse SAR (ISAR) address the fundamental challenges of cost-effectiveness and scalability inherent to near-field imaging. In this paper, near-field MIMO-ISAR mmWave imaging systems are discussed and developed. The rotational ISAR (R-ISAR) regime investigated in this paper requires rotating the target at a constant radial distance from the transceiver and scanning the transceiver along a vertical track. Using a 77GHz mmWave radar, a high resolution three-dimensional (3-D) image can be reconstructed from this two-dimensional scanning taking into account the spherical near-field wavefront. While prior work in literature consists of single-input-single-output circular synthetic aperture radar (SISO-CSAR) algorithms or computationally sluggish MIMO-CSAR image reconstruction algorithms, this paper proposes a novel algorithm for efficient MIMO 3-D holographic imaging and details the design of a MIMO R-ISAR imaging system. The proposed algorithm applies a multistatic-to-monostatic phase compensation to the R-ISAR regime allowing for use of highly efficient monostatic algorithms. We demonstrate the algorithm's performance in real-world imaging scenarios on a prototyped MIMO R-ISAR platform. Our fully integrated system, consisting of a mechanical scanner and efficient imaging algorithm, is capable of pairing the scanning efficiency of the MIMO regime with the computational efficiency of single pixel image reconstruction algorithms.

The challenge of image-based 3D reconstruction for glossy objects lies in separating diffuse and specular components on glossy surfaces from captured images, a task complicated by the ambiguity in discerning lighting conditions and material properties using RGB data alone. While state-of-the-art methods rely on tailored and/or high-end equipment for data acquisition, which can be cumbersome and time-consuming, this work introduces a scalable polarization-aided approach that employs cost-effective acquisition tools. By attaching a linear polarizer to readily available RGB cameras, multi-view polarization images can be captured without the need for advance calibration or precise measurements of the polarizer angle, substantially reducing system construction costs. The proposed approach represents polarimetric BRDF, Stokes vectors, and polarization states of object surfaces as neural implicit fields. These fields, combined with the polarizer angle, are retrieved by optimizing the rendering loss of input polarized images. By leveraging fundamental physical principles for the implicit representation of polarization rendering, our method demonstrates superiority over existing techniques through experiments in public datasets and real captured images on both reconstruction and novel view synthesis.

Satellite optical images, upon their on-ground receipt, offer a distorted view of the observed scene. Their restoration, including denoising, deblurring, and sometimes super-resolution, is required before their exploitation. Moreover, quantifying the uncertainties related to this restoration helps to reduce the risks of misinterpreting the image content. Deep learning methods are now state-of-the-art for satellite image restoration. Among them, direct inversion methods train a specific network for each sensor, and generally provide a point estimation of the restored image without the associated uncertainties. Alternatively, deep regularization (DR) methods learn a deep prior on target images before plugging it, as the regularization term, into a model-based optimization scheme. This allows for restoring images from several sensors with a single network and possibly for estimating associated uncertainties. In this paper, we introduce VBLE-xz, a DR method that solves the inverse problem in the latent space of a variational compressive autoencoder (CAE). We adapt the regularization strength by modulating the bitrate of the trained CAE with a training-free approach. Then, VBLE-xz estimates relevant uncertainties jointly in the latent and in the image spaces by sampling an explicit posterior estimated within variational inference. This enables fast posterior sampling, unlike state-of-the-art DR methods that use Markov chains or diffusion-based approaches. We conduct a comprehensive set of experiments on very high-resolution simulated and real Pléiades images, asserting the performance, robustness and scalability of the proposed method. They demonstrate that VBLE-xz represents a compelling alternative to direct inversion methods when uncertainty quantification is required. The code associated to this paper is available in https://github.com/MaudBqrd/VBLExz.

Dynamic imaging is a beneficial tool for interventions to assess physiological changes. Nonetheless during dynamic MRI, while achieving a high temporal resolution, the spatial resolution is compromised. To overcome this spatio-temporal trade-off, this research presents a super-resolution (SR) MRI reconstruction with prior knowledge based fine-tuning to maximise spatial information while reducing the required scan-time for dynamic MRIs. An U-Net based network with perceptual loss is trained on a benchmark dataset and fine-tuned using one subject-specific static high resolution MRI as prior knowledge to obtain high resolution dynamic images during the inference stage. 3D dynamic data for three subjects were acquired with different parameters to test the generalisation capabilities of the network. The method was tested for different levels of in-plane undersampling for dynamic MRI. The reconstructed dynamic SR results after fine-tuning showed higher similarity with the high resolution ground-truth, while quantitatively achieving statistically significant improvement. The average SSIM of the lowest resolution experimented during this research (6.25~\% of the k-space) before and after fine-tuning were 0.939 pm 0.008 and 0.957 pm 0.006 respectively. This could theoretically result in an acceleration factor of 16, which can potentially be acquired in less than half a second. The proposed approach shows that the super-resolution MRI reconstruction with prior-information can alleviate the spatio-temporal trade-off in dynamic MRI, even for high acceleration factors.

In this paper we consider the problem of acoustic inversion in the context of the optoacoustic tomography image reconstruction problem. By leveraging the ability of the recently proposed diffusion models for image generative tasks among others, we devise an image reconstruction architecture based on a conditional diffusion process. The scheme makes use of an initial image reconstruction, which is preprocessed by an autoencoder to generate an adequate representation. This representation is used as conditional information in a generative diffusion process. Although the computational requirements for training and implementing the architecture are not low, several design choices discussed in the work were made to keep them manageable. Numerical results show that the conditional information allows to properly bias the parameters of the diffusion model to improve the quality of the initial reconstructed image, eliminating artifacts or even reconstructing finer details of the ground-truth image that are not recoverable by the initial image reconstruction method. We also tested the proposal under experimental conditions and the obtained results were in line with those corresponding to the numerical simulations. Improvements in image quality up to 17 % in terms of peak signal-to-noise ratio were observed.

This paper proposes a new two-step procedure for sparse-view tomographic image reconstruction. It is called RISING, since it combines an early-stopped Rapid Iterative Solver with a subsequent Iteration Network-based Gaining step. So far, regularized iterative methods have widely been used for X-ray computed tomography image reconstruction from low-sampled data, since they converge to a sparse solution in a suitable domain, as upheld by the Compressed Sensing theory. Unfortunately, their use is practically limited by their high computational cost which imposes to perform only a few iterations in the available time for clinical exams. Data-driven methods, using neural networks to post-process a coarse and noisy image obtained from geometrical algorithms, have been recently studied and appreciated for both their computational speed and accurate reconstructions. However, there is no evidence, neither theoretically nor numerically, that neural networks based algorithms solve the mathematical inverse problem modeling the tomographic reconstruction process. In our two-step approach, the first phase executes very few iterations of a regularized model-based algorithm whereas the second step completes the missing iterations by means of a neural network. The resulting hybrid deep-variational framework preserves the convergence properties of the iterative method and, at the same time, it exploits the computational speed and flexibility of a data-driven approach. Experiments performed on a simulated and a real data set confirm the numerical and visual accuracy of the reconstructed RISING images in short computational times.

Fluorescence Lifetime Imaging (FLI) is a critical molecular imaging modality that provides unique information about the tissue microenvironment, which is invaluable for biomedical applications. FLI operates by acquiring and analyzing photon time-of-arrival histograms to extract quantitative parameters associated with temporal fluorescence decay. These histograms are influenced by the intrinsic properties of the fluorophore, instrument parameters, time-of-flight distributions associated with pixel-wise variations in the topographic and optical characteristics of the sample. Recent advancements in Deep Learning (DL) have enabled improved fluorescence lifetime parameter estimation. However, existing models are primarily designed for planar surface samples, limiting their applicability in translational scenarios involving complex surface profiles, such as in-vivo whole-animal or imaged guided surgical applications. To address this limitation, we present MFliNet (Macroscopic FLI Network), a novel DL architecture that integrates the Instrument Response Function (IRF) as an additional input alongside experimental photon time-of-arrival histograms. Leveraging the capabilities of a Differential Transformer encoder-decoder architecture, MFliNet effectively focuses on critical input features, such as variations in photon time-of-arrival distributions. We evaluate MFliNet using rigorously designed tissue-mimicking phantoms and preclinical in-vivo cancer xenograft models. Our results demonstrate the model's robustness and suitability for complex macroscopic FLI applications, offering new opportunities for advanced biomedical imaging in diverse and challenging settings.

The carbonized papyri from Herculaneum preserve the only large-scale library to survive from classical antiquity, but many unopened rolls remain unread because physical opening risks irreversible damage. X-ray computed microtomography (μCT) and virtual unwrapping offer a non-invasive route to their texts, yet previous work on sealed Herculaneum scrolls has recovered only localized readings or limited surface regions. Here, using high-resolution phase-contrast μCT acquired on the BM18 beamline at the European Synchrotron Radiation Facility (ESRF), together with improved computational unrolling and machine learning, we achieve the complete virtual unwrapping and reading of PHerc. 1667 under explicit coverage and papyrological-review criteria. This makes PHerc. 1667 the first Herculaneum papyrus to be fully digitally unrolled and read for extended scholarly study without physical opening. In PHerc. Paris 4, the optimized scan protocol makes ink directly visible in the tomographic volume, allowing three-dimensional ink segmentation and independent validation of surface-conditioned ink recovery. In PHerc. 139, we recover title and author-attribution evidence identifying the scroll as Philodemus, On Gods, Book 8. These results move virtual unwrapping of the Herculaneum scrolls beyond isolated demonstrations towards a scalable framework for systematic recovery of the still-unopened library.

Image registration is fundamental in medical imaging, enabling precise alignment of anatomical structures for diagnosis, treatment planning, image-guided treatment or longitudinal monitoring. This work introduces IMPACT (Image Metric with Pretrained model-Agnostic Comparison for Transmodality registration), a generic semantic similarity metric designed for seamless integration into diverse image registration frameworks (such as Elastix and Voxelmorph). It compares deep learning-based features extracted from medical images without requiring task-specific training, ensuring broad applicability across various modalities. By leveraging the features of the large-scale pretrained TotalSegmentator models and the ability to integrate Segment Anything Model (SAM) and other large-scale segmentation networks, this approach offers significant advantages. It provides robust, scalable, and efficient solutions for multimodal image registration. The IMPACT loss was evaluated on five challenging registration tasks involving thoracic CT/CBCT, and pelvic MR/CT datasets. Quantitative metrics, such as Target Registration Error and Dice Similarity Coefficient, demonstrated significant improvements in anatomical alignment compared to baseline methods. Qualitative analyses further confirmed the increased robustness of the proposed metric in the face of noise, artifacts, and modality variations. IMPACT's versatility and efficiency make it a valuable tool for advancing registration performance in clinical and research applications, addressing critical challenges in multimodal medical imaging.

Scene reconstruction in the presence of high-speed motion and low illumination is important in many applications such as augmented and virtual reality, drone navigation, and autonomous robotics. Traditional motion estimation techniques fail in such conditions, suffering from too much blur in the presence of high-speed motion and strong noise in low-light conditions. Single-photon cameras have recently emerged as a promising technology capable of capturing hundreds of thousands of photon frames per second thanks to their high speed and extreme sensitivity. Unfortunately, traditional computer vision techniques are not well suited for dealing with the binary-valued photon data captured by these cameras because these are corrupted by extreme Poisson noise. Here we present a method capable of estimating extreme scene motion under challenging conditions, such as low light or high dynamic range, from a sequence of high-speed image frames such as those captured by a single-photon camera. Our method relies on iteratively improving a motion estimate by grouping and aggregating frames after-the-fact, in a stratified manner. We demonstrate the creation of high-quality panoramas under fast motion and extremely low light, and super-resolution results using a custom single-photon camera prototype. For code and supplemental material see our https://wisionlab.com/project/panoramas-from-photons/{project webpage}.

Solid-state quantum emitters have emerged as a leading quantum memory for quantum networking applications. However, standard optical characterization techniques are neither efficient nor repeatable at scale. In this work, we introduce and demonstrate spectroscopic techniques that enable large-scale, automated characterization of color centers. We first demonstrate the ability to track color centers by registering them to a fabricated machine-readable global coordinate system, enabling systematic comparison of the same color center sites over many experiments. We then implement resonant photoluminescence excitation in a widefield cryogenic microscope to parallelize resonant spectroscopy, achieving two orders of magnitude speed-up over confocal microscopy. Finally, we demonstrate automated chip-scale characterization of color centers and devices at room temperature, imaging thousands of microscope fields of view. These tools will enable accelerated identification of useful quantum emitters at chip-scale, enabling advances in scaling up color center platforms for quantum information applications, materials science, and device design and characterization.

Most novel view synthesis methods such as NeRF are unable to capture the true high dynamic range (HDR) radiance of scenes since they are typically trained on photos captured with standard low dynamic range (LDR) cameras. While the traditional exposure bracketing approach which captures several images at different exposures has recently been adapted to the multi-view case, we find such methods to fall short of capturing the full dynamic range of indoor scenes, which includes very bright light sources. In this paper, we present PanDORA: a PANoramic Dual-Observer Radiance Acquisition system for the casual capture of indoor scenes in high dynamic range. Our proposed system comprises two 360{\deg} cameras rigidly attached to a portable tripod. The cameras simultaneously acquire two 360{\deg} videos: one at a regular exposure and the other at a very fast exposure, allowing a user to simply wave the apparatus casually around the scene in a matter of minutes. The resulting images are fed to a NeRF-based algorithm that reconstructs the scene's full high dynamic range. Compared to HDR baselines from previous work, our approach reconstructs the full HDR radiance of indoor scenes without sacrificing the visual quality while retaining the ease of capture from recent NeRF-like approaches.

Digital pathology enables automatic analysis of histopathological sections using artificial intelligence (AI). Automatic evaluation could improve diagnostic efficiency and help find associations between morphological features and clinical outcome. For development of such prediction models, identifying invasive epithelial cells, and separating these from benign epithelial cells and in situ lesions would be the first step. In this study, we aimed to develop an AI model for segmentation of epithelial cells in sections from breast cancer. We generated epithelial ground truth masks by restaining hematoxylin and eosin (HE) sections with cytokeratin (CK) AE1/AE3, and by pathologists' annotations. HE/CK image pairs were used to train a convolutional neural network, and data augmentation was used to make the model more robust. Tissue microarrays (TMAs) from 839 patients, and whole slide images from two patients were used for training and evaluation of the models. The sections were derived from four cohorts of breast cancer patients. TMAs from 21 patients from a fifth cohort was used as a second test set. In quantitative evaluation, a mean Dice score of 0.70, 0.79, and 0.75 for invasive epithelial cells, benign epithelial cells, and in situ lesions, respectively, were achieved. In qualitative scoring (0-5) by pathologists, results were best for all epithelium and invasive epithelium, with scores of 4.7 and 4.4. Scores for benign epithelium and in situ lesions were 3.7 and 2.0. The proposed model segmented epithelial cells in HE stained breast cancer slides well, but further work is needed for accurate division between the classes. Immunohistochemistry, together with pathologists' annotations, enabled the creation of accurate ground truths. The model is made freely available in FastPathology and the code is available at https://github.com/AICAN-Research/breast-epithelium-segmentation

The recent advent of 3D Gaussian Splatting (3DGS) has revolutionized the 3D scene reconstruction space enabling high-fidelity novel view synthesis in real-time. However, with the exception of RawNeRF, all prior 3DGS and NeRF-based methods rely on 8-bit tone-mapped Low Dynamic Range (LDR) images for scene reconstruction. Such methods struggle to achieve accurate reconstructions in scenes that require a higher dynamic range. Examples include scenes captured in nighttime or poorly lit indoor spaces having a low signal-to-noise ratio, as well as daylight scenes with shadow regions exhibiting extreme contrast. Our proposed method HDRSplat tailors 3DGS to train directly on 14-bit linear raw images in near darkness which preserves the scenes' full dynamic range and content. Our key contributions are two-fold: Firstly, we propose a linear HDR space-suited loss that effectively extracts scene information from noisy dark regions and nearly saturated bright regions simultaneously, while also handling view-dependent colors without increasing the degree of spherical harmonics. Secondly, through careful rasterization tuning, we implicitly overcome the heavy reliance and sensitivity of 3DGS on point cloud initialization. This is critical for accurate reconstruction in regions of low texture, high depth of field, and low illumination. HDRSplat is the fastest method to date that does 14-bit (HDR) 3D scene reconstruction in le15 minutes/scene (sim30x faster than prior state-of-the-art RawNeRF). It also boasts the fastest inference speed at ge120fps. We further demonstrate the applicability of our HDR scene reconstruction by showcasing various applications like synthetic defocus, dense depth map extraction, and post-capture control of exposure, tone-mapping and view-point.

Conditional diffusion inversion provides a powerful framework for unpaired image-to-image translation. However, we demonstrate through an extensive analysis that standard deterministic inversion (e.g. DDIM) fails when the source domain is spectrally sparse compared to the target domain (e.g., super-resolution, sketch-to-image). In these contexts, the recovered latent from the input does not follow the expected isotropic Gaussian distribution. Instead it exhibits a signal with lower frequencies, locking target sampling to oversmoothed and texture-poor generations. We term this phenomenon spectral collapse. We observe that stochastic alternatives attempting to restore the noise variance tend to break the semantic link to the input, leading to structural drift. To resolve this structure-texture trade-off, we propose Orthogonal Variance Guidance (OVG), an inference-time method that corrects the ODE dynamics to enforce the theoretical Gaussian noise magnitude within the null-space of the structural gradient. Extensive experiments on microscopy super-resolution (BBBC021) and sketch-to-image (Edges2Shoes) demonstrate that OVG effectively restores photorealistic textures while preserving structural fidelity.